ArticleNature genetics2016
Evolution of the immune system influences speciation rates in teleost fishes.
Article in Nature genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 128 papers.
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Who cites it
128 citing papers in PubMed, 268 citations in OpenAlex.
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- Loss of Major Histocompatibility Complex I and II Function in the Genome of Glacier Lanternfish Provides Insight Into Evolution of Vertebrate Immune Systems.Genome biology and evolution · 2026Article
- The Vertebrate Genomes Project Phase I: A global reference genome resource.bioRxiv : the preprint server for biology · 2026Article
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- Rapid genome modifications including chromosomal fusions and large-scale inversions are key features in Arctic codfish species.Genome biology · 2026Article
- Macroevolutionary changes in gene expression response to an immune stimulus across the diversity of fishes.Molecular biology and evolution · 2026Article
- TLR25 is endosomally located and responds toFrontiers in immunology · 2026Article
- IgM-mediated protection drives early B-cell activation and mucosal containment ofFrontiers in immunology · 2026Article
- Novel TRIM Proteins Modulating the Innate Immune Response of Rainbow Trout (Animals : an open access journal from MDPI · 2025Article
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- Diverse hosts, diverse immune systems: Evolutionary variation in bat immunology.Annals of the New York Academy of Sciences · 2025Review
- Convergent Evolution in Amblyopsid Cavefishes and the Age of Eastern North American Subterranean Ecosystems.Molecular biology and evolution · 2025Article
- Chromosomal Inversions Mediated by Tandem Insertions of Transposable Elements.Genome biology and evolution · 2025Article
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68 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Teleost fishes constitute the most species-rich vertebrate clade and exhibit extensive genetic and phenotypic variation, including diverse immune defense strategies. The genomic basis of a particularly aberrant strategy is exemplified by Atlantic cod, in which a loss of major histocompatibility complex (MHC) II functionality coincides with a marked expansion of MHC I genes. Through low-coverage genome sequencing (9-39×), assembly and comparative analyses for 66 teleost species, we show here that MHC II is missing in the entire Gadiformes lineage and thus was lost once in their common ancestor. In contrast, we find that MHC I gene expansions have occurred multiple times, both inside and outside this clade. Moreover, we identify an association between high MHC I copy number and elevated speciation rates using trait-dependent diversification models. Our results extend current understanding of the plasticity of the adaptive immune system and suggest an important role for immune-related genes in animal diversification.
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