ArticleNature neuroscience2016
Hypothalamic arcuate nucleus tyrosine hydroxylase neurons play orexigenic role in energy homeostasis.
Article in Nature neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 110 papers.
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Who cites it
110 citing papers in PubMed.
- Neuroendocrine regulation of appetite and energy balance in metabolic disorders.IBRO neuroscience reports · 2026Review
- A hypothalamic circuit links high-fat diet exposure to anxiety-like behavior and anxiety-associated hyperphagia.Nature communications · 2026Article
- Single-cell profiling identifies obesity-disrupted brain glucose sensing.Nature communications · 2026Article
- Lactation increases food seeking and palatable feeding through mesolimbic dopamine signaling in mice.Cell reports · 2026Article
- A Hypothalamic Inhibitory Circuit Encoding the Scalability of Stress Responses.bioRxiv : the preprint server for biology · 2026Article
- Mesolimbic dopamine signaling mediates increased hedonic feeding and food seeking in lactating mice.bioRxiv : the preprint server for biology · 2026Article
- Structural MRI assessment of hypothalamic alterations and cognitive implications in adolescents with rapid pubertal progression.BMC medical imaging · 2026Article
- GCGR agonism requires GABAergic signaling in the medial basal hypothalamus to promote weight loss in obese mice.Molecular metabolism · 2026Article
- Sex-specific differences in mediobasal hypothalamus in response to nutritional states.Nature communications · 2026Article
- DAPL1 is activated by Np63 and GRα and regulates lipid metabolism.Journal of molecular medicine (Berlin, Germany) · 2026Article
- Prolonged Aggressive Experience Accelerates Resolution of Inflammation in Blood and Microglia After Repeated LPS Treatment.International journal of molecular sciences · 2025Article
- Time-restricted feeding promotes glucagon-like peptide-1 secretion and regulates appetite via tryptophan metabolism of gutGut microbes · 2025Article
- Reflection and Experimental Rigor Are Our AiMS: A New Metacognitive Framework for Experimental Design.eNeuro · 2025Article
- Proneural gene Mash1 (Ascl1) is expressed in multiple lineages and regulates their differentiation and specification.Histochemistry and cell biology · 2025Review
- Regulation of Feeding Behavior and Body Weight by Orexigenic Neurons in the Arcuate Nucleus.Journal of obesity & metabolic syndrome · 2025Review
- An alternative neural basis underlying leptin resistance.Cell reports · 2025Article
- Motilin stimulates food intake linked to gastric motility inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- AgRP mediated calcium Inhibition of feeding via the vagal afferent nerve-brain pathway.Cell & bioscience · 2025Article
- α2-Adrenergic Receptors in Hypothalamic Dopaminergic Neurons: Impact on Food Intake and Energy Expenditure.International journal of molecular sciences · 2025Article
- The metabolic and cardiovascular effects of amphetamine are partially mediated by the central melanocortin system.Cell reports. Medicine · 2025Article
50 more citing papers are in PubMed but not listed here.
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2 authors.
Funding
Abstract
Energy homeostasis, food intake, and body weight are regulated by specific brain circuits. Here we introduce an unexpected neuron, the tyrosine hydroxylase (TH) neuron of the arcuate nucleus (ARC), that we show makes an orexigenic contribution. Optogenetic stimulation of mouse ARC TH neurons increased food intake; attenuating transmitter release reduced body weight. Optogenetic stimulation of ARC TH cells inhibited pro-opiomelanocortin (POMC) neurons through synaptic mechanisms. ARC TH cells project to the hypothalamic paraventricular nucleus; optogenetic stimulation of ARC TH axons inhibited paraventricular nucleus neurons by dopamine and GABA co-release. Dopamine excited orexigenic neurons that synthesize agouti-related peptide and neuropeptide Y but inhibited anorexigenic neurons that synthesize POMC, as determined by whole cell recording. Food deprivation increased c-fos expression and spike frequency in ARC TH neurons. The gut peptide ghrelin evoked direct excitatory effects, suggesting these neurons monitor metabolic cues. Together these data support the view that ARC TH cells play an unrecognized and influential positive role in energy homeostasis.
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