Evidence map›Paper›PMID 27547971›Full record

ArticlePloS one2016

Poor Cervical Cancer Screening Attendance and False Negatives. A Call for Organized Screening.

Marta Castillo, Aurora Astudillo, Omar Clavero, Julio Velasco, Raquel Ibáñez, Silvia de Sanjosé

Abstract read
In one paragraph

Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Trial
  2. HPV-related cancer prevention in Spain: progress and remaining challenges in vaccination, screening, and surveillance.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
    Review
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  11. Journal of clinical medicine · 2023
    Article
  12. Could HPV Type 33 Be More Risky Than We Thought?International journal of surgical pathology · 2023
    Article
  13. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Marta CastilloObstetrics and Gynecology Department, Jarrio Hospital, SESPA, Coaña, Asturias, Spain.
Aurora AstudilloPathology Department, Asturias Central University Hospital, Oviedo University, SESPA, Oviedo, Asturias, Spain.
Omar ClaveroInfections and Cancer Unit, Cancer Epidemiology Research Programme, Institut Català d'Oncologia-IDIBELL, L´Hospitalet de Llobregat, Barcelona, Spain.
Julio VelascoPathology Department, Medical Center of Asturias, Oviedo, Asturias, Spain.
Raquel IbáñezInfections and Cancer Unit, Cancer Epidemiology Research Programme, Institut Català d'Oncologia-IDIBELL, L´Hospitalet de Llobregat, Barcelona, Spain.
Silvia de SanjoséInfections and Cancer Unit, Cancer Epidemiology Research Programme, Institut Català d'Oncologia-IDIBELL, L´Hospitalet de Llobregat, Barcelona, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe objective of this study was to describe prior negative screening history and symptoms around the time of diagnosis of incident cervical cancer (CC) cases diagnosed between 2000 and 2010 within the Asturias public health system.

methodsRecords from 374 women diagnosed with CC between 2000 and 2010 from all public hospitals in Asturias were retrieved. Clinical information, FIGO stage and all previous cytological data were extracted from clinical and histopathological records. Proportional differences were assessed using chi-square tests. Logistic regression analysis was used to estimate odds ratios (OR) and 95% confidence intervals (CI). Inter-observer agreement in cytology was checked by comparing concordance values using k-statistics.

resultsNo prior screening history was recorded in 60.7% of CC cases and its absence increased with age and advanced stage. Advanced stage (e.g., ≥ II) at diagnosis was associated with age (>50 years) and adenocarcinoma (ADC) compared to younger women and those with a squamous cell carcinoma (SCC). False negative smears were identified in 27.1% of women with CC (ADC 52.6% vs. SCC 16.2%, p<0.05).

conclusionsAbsence of prior screening history was common among CC cases. Organized actions to reduce "under screening" and the use of highly sensitive HPV-based tests could be useful strategies in reducing the burden of CC in Asturias.

Indexed as

Delayed DiagnosisAdenocarcinomaAdultAgedAged, 80 and overCarcinoma, Squamous CellDiagnostic ErrorsEarly Detection of CancerFalse Negative ReactionsFemaleHumansIncidental FindingsMiddle AgedObserver VariationOdds RatioPublic Health Surveillance

Identifiers

PMID27547971
PMCPMC4993473

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.