Evidence map›Paper›PMID 27547955›Full record

ArticlePloS one2016

Feasibility Study of the Permeability and Uptake of Mesoporous Silica Nanoparticles across the Blood-Brain Barrier.

Habib Baghirov, Didem Karaman, Tapani Viitala, Alain Duchanoy, Yan-Ru Lou, Veronika Mamaeva, Evgeny Pryazhnikov, Leonard Khiroug, Catharina de Lange Davies, Cecilia Sahlgren and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
5.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 106 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Habib BaghirovTurku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland.
Didem KaramanLaboratory of Physical Chemistry, Faculty of Science and Engineering, Åbo Akademi University, Turku, Finland.
Tapani ViitalaCentre for Drug Research, Division of Pharmaceutical Biosciences, University of Helsinki, Helsinki, Finland.
Alain DuchanoyLaboratory of Physical Chemistry, Faculty of Science and Engineering, Åbo Akademi University, Turku, Finland.
Yan-Ru LouCentre for Drug Research, Division of Pharmaceutical Biosciences, University of Helsinki, Helsinki, Finland.
Veronika MamaevaTurku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland.
Evgeny PryazhnikovNeurotar LtD, Helsinki, Finland.
Leonard KhirougNeurotar LtD, Helsinki, Finland.
Catharina de Lange DaviesDepartment of Physics, Norwegian University of Science and Technology, Trondheim, Norway.
Cecilia SahlgrenTurku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland.
Jessica M RosenholmLaboratory of Physical Chemistry, Faculty of Science and Engineering, Åbo Akademi University, Turku, Finland.
Åbo Akademi University · FINorwegian University of Science and Technology · NOUniversity of Helsinki · FITurku Centre for Biotechnology · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Drug delivery into the brain is impeded by the blood-brain-barrier (BBB) that filters out the vast majority of drugs after systemic administration. In this work, we assessed the transport, uptake and cytotoxicity of promising drug nanocarriers, mesoporous silica nanoparticles (MSNs), in in vitro models of the BBB. RBE4 rat brain endothelial cells and Madin-Darby canine kidney epithelial cells, strain II, were used as BBB models. We studied spherical and rod-shaped MSNs with the following modifications: bare MSNs and MSNs coated with a poly(ethylene glycol)-poly(ethylene imine) (PEG-PEI) block copolymer. In transport studies, MSNs showed low permeability, whereas the results of the cellular uptake studies suggest robust uptake of PEG-PEI-coated MSNs. None of the MSNs showed significant toxic effects in the cell viability studies. While the shape effect was detectable but small, especially in the real-time surface plasmon resonance measurements, coating with PEG-PEI copolymers clearly facilitated the uptake of MSNs. Finally, we evaluated the in vivo detectability of one of the best candidates, i.e. the copolymer-coated rod-shaped MSNs, by two-photon in vivo imaging in the brain vasculature. The particles were clearly detectable after intravenous injection and caused no damage to the BBB. Thus, when properly designed, the uptake of MSNs could potentially be utilized for the delivery of drugs into the brain via transcellular transport.

Indexed as

Drug CarriersAnimalsBiological TransportBlood-Brain BarrierBrainCell LineCell SurvivalDogsEndothelial CellsInjections, IntravenousMadin Darby Canine Kidney CellsMiceMicroscopy, Fluorescence, MultiphotonModels, BiologicalMolecular ImagingNanoparticlesDrug Carrierspoly(ethylene glycol)-co-poly(ethyleneimine)Polyethylene GlycolsPolyethyleneimineSilicon Dioxide

Identifiers

PMID27547955
PMCPMC4993362
OpenAlexW2513498847

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.