ArticlePlant signaling & behavior2016
Arabidopsis DDB1-CUL4 E3 ligase complexes in det1 salt/osmotic stress resistant germination.
Article in Plant signaling & behavior, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Global analysis of soybean bZIP gene family under stress and identification of salt-stress-responsive candidate genes.Frontiers in plant science · 2026Article
- GWAS and gene co-expression network analysis reveal the genetic control of seed germination under salt stress in maize.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- QTL mapping and transcriptome analysis of seed germination under PEG-induced water stress in Lactuca spp.Scientific reports · 2024Article
- Article
- OsCBE1, a Substrate Receptor of Cullin4-Based E3 Ubiquitin Ligase, Functions as a Regulator of Abiotic Stress Response and Productivity in Rice.International journal of molecular sciences · 2021Article
- Enhanced Reproductive Thermotolerance of the TomatoFrontiers in plant science · 2021Article
- Role of Arabidopsis ABF1/3/4 during det1 germination in salt and osmotic stress conditions.Plant molecular biology · 2018Article
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2 authors.
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Abstract
A key regulatory mechanism in plant growth, development, and stress signaling utilizes E3 ubiquitin ligases, which target a variety of substrates for degradation. DE-ETIOLATED 1 (DET1) forms a complex with DDB1 (DAMAGED DNA BINDING protein 1) and CUL4 (CULLIN 4), and negatively regulates light signaling. Another DDB1-CUL4 complex containing DWA1 and DWA2 (DWD hypersensitive to ABA 1 and 2) has been shown to negatively regulate abscisic acid (ABA) signaling. Since distinct DDB1-CUL4 complexes have been shown to influence each other, we analyzed genetic interactions between DET1 and components of DDB1-CUL4 complexes during seed germination under salt and osmotic stress conditions. det1 germination was resistant to salt and osmotic stress and dwa1 and dwa2 enhanced this phenotype. In contrast, ddb1a partially suppressed the det1 germination phenotype on both salt and mannitol, while ddb1b had no effect. Mutations in DDB2, a DDB1-CUL4 complex component involved in DNA repair, also partially suppressed the det1 germination phenotype while mutants in COP1, another light signaling component, completely suppressed the det1 resistant germination phenotypes. Taken together these data suggest that components of E3 ubiquitin ligase complexes have variable but significant effects on det1 salt/osmotic stress responses.
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