Evidence map›Paper›PMID 27547823›Full record

ArticleJCI insight2016

IL4RA on lymphatic endothelial cells promotes T cell egress during sclerodermatous graft versus host disease.

Katia Urso, David Alvarez, Viviana Cremasco, Kelly Tsang, Angelo Grauel, Robert Lafyatis, Ulrich H von Andrian, Joerg Ermann, Antonios O Aliprantis

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JCI insight, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Leukocyte Trafficking in Lymphatic Vessels.Cold Spring Harbor perspectives in medicine · 2022
    Review
  2. Article
  3. Article
  4. Lymphatic endothelial cells of the lymph node.Nature reviews. Immunology · 2020
    Review
  5. Article
  6. Lymphatics in the liver.Current opinion in immunology · 2018
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Katia UrsoDepartment of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
David AlvarezDepartment of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, USA.
Viviana CremascoDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Kelly TsangDepartment of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Angelo GrauelDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Robert LafyatisDepartment of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA.
Ulrich H von AndrianDepartment of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, USA; Ragon Institute of Massachusetts General Hospital (MGH), MIT, and Harvard, Cambridge, Massachusetts, USA.
Joerg ErmannDepartment of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Antonios O AliprantisDepartment of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Harvard University · USDana-Farber Cancer Institute · USBoston University · USBrigham and Women's Hospital · US

Funding

TCR recognition of MHC class II peptide compexes in multiple sclerosisP01AI045757 · NIAID · DANA-FARBER CANCER INSTITUTE · PI WUCHERPFENNIG, KAI W · 1999 to 2017
$22.8M
Tetramer CoreU19AI095261 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI VON ANDRIAN, ULRICH H · 2011 to 2015
$10.8M
TRANSFUSION BIOLOGY AND MEDICINET32HL066987 · NHLBI · CHILDREN'S HOSPITAL BOSTON · PI JOHN P MANIS · 2001 to 2026
$10.2M
P3: Chemokine-Mediated T Cell Trafficking in HIV Transmission and Immune ResponseP01AI112521 · NIAID · HARVARD MEDICAL SCHOOL · PI VON ANDRIAN, ULRICH H · 2014 to 2018
$9.8M
Generation and Function of NK Cell MemoryR01AI111595 · NIAID · HARVARD MEDICAL SCHOOL · PI VON ANDRIAN, ULRICH H · 2013 to 2017
$4.1M
Rheumatic Diseases Research Core CentersP30AR061271 · NIAMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BHAWAN, JAG · 2011 to 2015
$3.1M
Innate immunity in dermal fibrosis and systemic sclerosisR01AR051089 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LAFYATIS, ROBERT A. · 2005 to 2015
$2.8M
Targeting tumor desmoplasia to harness cytotoxic immune responsesR21CA182598 · NCI · DANA-FARBER CANCER INST · PI CREMASCO, VIVIANA · 2014 to 2015
$407k
Analyzing Disease Mechanisms in a Mouse Model of SpondyloarthritisR03AR066357 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI ERMANN, JOERG · 2014 to 2016
$236k
NCI NIH HHS R21 CA182598NHLBI NIH HHS T32 HL066987NIAID NIH HHS P01 AI045757NIAID NIH HHS P01 AI112521NIAID NIH HHS R01 AI111595NIAID NIH HHS U19 AI095261NIAMS NIH HHS P30 AR061271NIAMS NIH HHS R01 AR051089NIAMS NIH HHS R03 AR066357
6 · The paper itself

Abstract

Systemic sclerosis (SSc) is a potentially fatal autoimmune disorder with limited therapeutic options. Sclerodermatous graft versus host disease (sclGvHD), induced by transfer of B10.D2 splenocytes into BALB/c

Identifiers

PMID27547823
PMCPMC4988402
OpenAlexW2476233518

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.