Evidence map›Paper›PMID 27547819›Full record

ArticleACS infectious diseases2016

Structure of the Essential

Misty L Kuhn, Evan Alexander, George Minasov, Holland J Page, Zdzislaw Warwrzak, Ludmilla Shuvalova, Kristin J Flores, Daniel J Wilson, Ce Shi, Courtney C Aldrich and 1 more

Open access · greenAbstract read
In one paragraph

Article in ACS infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 51 citations in OpenAlex.

  1. Article
  2. Structural Basis for the Catalytic Mechanism of ATP-Dependent Diazotase CmaA6.Angewandte Chemie (International ed. in English) · 2025
    Article
  3. Article
  4. Article
  5. The Structural and Molecular Mechanisms ofMolecules (Basel, Switzerland) · 2024
    Review
  6. Genome sequence ofMicrobiology resource announcements · 2023
    Article
  7. Structural basis for the development of potential inhibitors targeting FadD23 from Mycobacterium tuberculosis.Acta crystallographica. Section F, Structural biology communications · 2023
    Article
  8. Mechanisms of Linezolid Resistance in Mycobacteria.Pharmaceuticals (Basel, Switzerland) · 2023
    Review
  9. Molecular Mechanisms of MmpL3 Function and Inhibition.Microbial drug resistance (Larchmont, N.Y.) · 2023
    Review
  10. Tuberculosis: Pathogenesis, Current Treatment Regimens and New Drug Targets.International journal of molecular sciences · 2023
    Review
  11. The Key Roles ofFrontiers in microbiology · 2023
    Article
  12. Review
  13. Article
  14. OvercomingActa pharmaceutica Sinica. B · 2022
    Review
  15. In Silico Drug Repurposing Approach: Investigation ofMolecules (Basel, Switzerland) · 2022
    Article
  16. Article
  17. Genome mining for drug discovery: cyclic lipopeptides related to daptomycin.Journal of industrial microbiology & biotechnology · 2021
    Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Misty L KuhnCenter for Structural Genomics of Infectious Diseases, Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, United States; Center for Drug Design, University of Minnesota, Minneapolis, Minnesota 55455, United States.
Evan AlexanderDepartment of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, United States.
George MinasovCenter for Structural Genomics of Infectious Diseases, Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, United States.
Holland J PageCenter for Drug Design, University of Minnesota, Minneapolis, Minnesota 55455, United States.
Zdzislaw WarwrzakDepartment of Chemistry and Biochemistry, San Francisco State University, San Francisco, California 94132, United States.
Ludmilla ShuvalovaCenter for Structural Genomics of Infectious Diseases, Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, United States.
Kristin J FloresCenter for Structural Genomics of Infectious Diseases, Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, United States.
Daniel J WilsonDepartment of Chemistry and Biochemistry, San Francisco State University, San Francisco, California 94132, United States.
Ce ShiDepartment of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, United States.
Courtney C AldrichDepartment of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, United States; Department of Chemistry and Biochemistry, San Francisco State University, San Francisco, California 94132, United States.
Wayne F AndersonCenter for Structural Genomics of Infectious Diseases, Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, United States.
Northwestern University · USSan Francisco State University · USUniversity of Minnesota · US

Funding

Vaccines and Therapies Against BotulismU54AI057153 · NIAID · UNIVERSITY OF CHICAGO · PI FISCHETTI, VINCENT A. · 2003 to 2013
$87.6M
Design of Antituberculosis Agents that Target Siderophore BiosynthesisR01AI070219 · NIAID · UNIVERSITY OF MINNESOTA · PI ALDRICH, COURTNEY C · 2006 to 2013
$2.2M
NIAID NIH HHS HHSN272200700058CNIAID NIH HHS HHSN272201200026CNIAID NIH HHS R01 AI070219NIAID NIH HHS U54 AI057153
6 · The paper itself

Abstract

Mycolic acids are indispensible lipids of

Indexed as

FadD32fatty acyl-AMP ligaseMycobacterium tuberculosismycolic acid biosynthesis

Identifiers

PMID27547819
PMCPMC4989915
OpenAlexW2464708224

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.