Evidence map›Paper›PMID 27547815›Full record

ArticleEndoscopy international open2016

Comparison of the endocytoscopic and clinicopathologic features of colorectal neoplasms.

Kenichi Takeda, Shin-Ei Kudo, Masashi Misawa, Yuichi Mori, Toyoki Kudo, Kenta Kodama, Kunihiko Wakamura, Hideyuki Miyachi, Eiji Hidaka, Fumio Ishida and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Endoscopy international open, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kenichi TakedaDigestive Disease Center, Showa University, Yokohama Northern Hospital, Kanagawa, Japan.
Shin-Ei KudoDigestive Disease Center, Showa University, Yokohama Northern Hospital, Kanagawa, Japan.
Masashi MisawaDigestive Disease Center, Showa University, Yokohama Northern Hospital, Kanagawa, Japan.
Yuichi MoriDigestive Disease Center, Showa University, Yokohama Northern Hospital, Kanagawa, Japan.
Toyoki KudoDigestive Disease Center, Showa University, Yokohama Northern Hospital, Kanagawa, Japan.
Kenta KodamaDigestive Disease Center, Showa University, Yokohama Northern Hospital, Kanagawa, Japan.
Kunihiko WakamuraDigestive Disease Center, Showa University, Yokohama Northern Hospital, Kanagawa, Japan.
Hideyuki MiyachiDigestive Disease Center, Showa University, Yokohama Northern Hospital, Kanagawa, Japan.
Eiji HidakaDigestive Disease Center, Showa University, Yokohama Northern Hospital, Kanagawa, Japan.
Fumio IshidaDigestive Disease Center, Showa University, Yokohama Northern Hospital, Kanagawa, Japan.
Haruhiro InoueDigestive Disease Center, Showa University, Koto Toyosu Hospital, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimPermeation of a vein or lymphatic vessel by a tumor is a key risk factor for lymph node metastasis. We examined the features of colorectal tumor vessel permeation using endocytoscopy, an ultra-high magnifying endoscopic system combined with a narrow-band imaging capability (EC-NBI). PATIENTS AND

methodsWe examined 188 colorectal lesions using EC-NBI before treatment was started. We measured the diameters of tumor vessels on EC-NBI images. We used the tumor vessel diameter (the mean diameter of four tumor-associated vessels) and the variation in tumor vessel caliber (the difference between the maximum and minimum diameters of the vessels expressed as a proportion) to judge changes in vessel formation. We examined the relationship between these variables and the extent of venous or lymphatic vessel permeation (vessel invasion) established by immunohistochemical examination of the resected specimen using monoclonal antibodies against the CD34 and D2 - 40 antigens. We also analyzed the relationships between tumor vessel diameter, tumor vessel caliber variation, and depth of tumor invasion.

resultsThere were significant differences in tumor vessel diameter and caliber variation between tumors in situ and T1 - T3 carcinomas. In T1 carcinomas, larger tumor vessel diameter and greater tumor vessel caliber variation were significantly associated with venous permeation. In T2 and T3 carcinomas, greater tumor vessel caliber variation was significantly associated with venous permeation.

conclusionsThe vessel diameter and caliber variation of colorectal tumor microvasculature are associated with depth of invasion and venous permeation, especially in T1 carcinomas.

Identifiers

PMID27547815
PMCPMC4990025

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.