ArticleAnnals of clinical and translational neurology2016
Alzheimer's disease: are blood and brain markers related? A systematic review.
Article in Annals of clinical and translational neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The trial behind it
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Who cites it
14 citing papers in PubMed.
- Integrated machine learning identifies biomarkers for bilirubin-induced Alzheimer's disease-like lesions in neonates and adults.Scientific reports · 2025Article
- Biomarker Profile in Peripheral Blood Cells Related to Alzheimer's Disease.Molecular neurobiology · 2025Article
- Attitudes of Family Members and Caregivers Regarding Alzheimer's Disease Pre-Symptomatic Screening.Journal of Alzheimer's disease reports · 2024Article
- Joint triplet loss with semi-hard constraint for data augmentation and disease prediction using gene expression data.Scientific reports · 2023Article
- Correlation between Alzheimer's disease and type 2 diabetes using non-negative matrix factorization.Scientific reports · 2021Article
- The plasma peptides of Alzheimer's disease.Clinical proteomics · 2021Article
- Nanoparticle-Enabled Enrichment of Longitudinal Blood Proteomic Fingerprints in Alzheimer's Disease.ACS nano · 2021Article
- Proteomic analysis of the monkey hippocampus for elucidating ischemic resistance.Journal of clinical biochemistry and nutrition · 2020Article
- A programmable polymer library that enables the construction of stimuli-responsive nanocarriers containing logic gates.Nature chemistry · 2020Article
- Discovery and validation of plasma proteomic biomarkers relating to brain amyloid burden by SOMAscan assay.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2019Article
- Peripheral transcriptomic biomarkers for early detection of sporadic Alzheimer disease?Dialogues in clinical neuroscience · 2018Review
- A proteomic approach reveals the differential protein expression inJournal of ginseng research · 2018Article
- Article
- A Decade of Blood Biomarkers for Alzheimer's Disease Research: An Evolving Field, Improving Study Designs, and the Challenge of Replication.Journal of Alzheimer's disease : JAD · 2018Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
objectivePeripheral protein biomarkers of Alzheimer's disease (AD) may help identify novel treatment avenues by allowing early diagnosis, recruitment to clinical trials, and treatment initiation. The purpose of this review was to determine which proteins have been found to be differentially expressed in the AD brain and whether these proteins are also found within the blood of AD patients.
methodsA two-stage approach was conducted. The first stage involved conducting a systematic search to identify discovery-based brain proteomic studies of AD. The second stage involved comparing whether proteins found to be differentially expressed in AD brain were also differentially expressed in the blood.
resultsAcross 11 discovery based brain proteomic studies 371 proteins were at different levels in the AD brain. Nine proteins were frequently found, defined as appearing in at least three separate studies. Of these proteins heat-shock cognate 71 kDa, ubiquitin carboxyl-terminal hydrolase isozyme L1, and 2',3'-cyclic nucleotide 3' phosphodiesterase alone were found to share a consistent direction of change, being consistently upregulated in studies they appeared in. Eighteen proteins seen as being differentially expressed within the AD brain were present in blood proteomic studies of AD. Only complement C4a was seen multiple times within both the blood and brain proteomic studies.
interpretationWe report a number of proteins appearing in both the blood and brain of AD patients. Of these proteins, C4a may be a good candidate for further follow-up in large-scale replication efforts.
Identifiers
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Registered trials
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