Evidence map›Paper›PMID 27547746›Full record

ArticleThe journal of prevention of Alzheimer's disease2016

Neuropsychological Profile of "Cognitive Frailty" Subjects in MAPT Study.

J Delrieu, S Andrieu, M Pahor, C Cantet, M Cesari, P J Ousset, T Voisin, B Fougère, S Gillette, I Carrie and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of prevention of Alzheimer's disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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  7. Impact of multidomain lifestyle intervention on dynamics of cognitive frailty: post hoc analysis of the FINGER trial.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

J DelrieuGérontopôle, Alzheimer's Disease Research and Clinical Center, Toulouse University Hospital, Toulouse, France; INSERM U 1027, Toulouse, France.
S AndrieuINSERM U 1027, Toulouse, France.
M PahorDepartment of Aging and Geriatric Research, University of Florida-Institute on Aging, Gainesville, FL, USA.
C CantetINSERM U 1027, Toulouse, France.
M CesariGérontopôle, Alzheimer's Disease Research and Clinical Center, Toulouse University Hospital, Toulouse, France; INSERM U 1027, Toulouse, France.
P J OussetGérontopôle, Alzheimer's Disease Research and Clinical Center, Toulouse University Hospital, Toulouse, France; INSERM U 1027, Toulouse, France.
T VoisinGérontopôle, Alzheimer's Disease Research and Clinical Center, Toulouse University Hospital, Toulouse, France; INSERM U 1027, Toulouse, France.
B FougèreGérontopôle, Alzheimer's Disease Research and Clinical Center, Toulouse University Hospital, Toulouse, France.
S GilletteGérontopôle, Alzheimer's Disease Research and Clinical Center, Toulouse University Hospital, Toulouse, France; INSERM U 1027, Toulouse, France.
I CarrieGérontopôle, Alzheimer's Disease Research and Clinical Center, Toulouse University Hospital, Toulouse, France.
B VellasGérontopôle, Alzheimer's Disease Research and Clinical Center, Toulouse University Hospital, Toulouse, France; INSERM U 1027, Toulouse, France.

Funding

University of Florida Older Americans Independence Center (OAIC)P30AG028740 · NIA · UNIVERSITY OF FLORIDA · PI CHRISTIAAN LEEUWENBURGH · 2007 to 2026
$22.8M
NIA NIH HHS P30 AG028740PHS HHS
6 · The paper itself

Abstract

objectivesAn international group proposed the existence of "cognitive frailty", a condition defined by simultaneous presence of physical frailty and cognitive impairment in the absence of dementia. The objective was to compare the neuropsychological profiles in subgroups of elders differentiated across their physical frailty (Fried phenotype) and cognitive status (Clinical Dementia Rating score) to characterize the "cognitive frailty" entity.

methodWe studied baseline characteristics of 1,617 subjects enrolled in Multidomain Alzheimer Disease Preventive Trial (MAPT). Included subjects were aged 70 years or older and presented at least 1 of the 3 following clinical criteria: (1) Memory complaint spontaneously reported to a general practitioner, (2) limitation in one instrumental activity of daily living, (3) slow gait speed. Subjects with dementia were not included in the trial.

results"Cognitive frailty individuals" significantly differed from "individuals with cognitive impairment and without physical frailty", scoring worse at executive, and attention tests. They presented subcortico-frontal cognitive pattern different of Alzheimer Disease. Cognitive performance of subjects with 3 criteria or more of the frailty phenotype are cognitively more impaired than subjects with only one. DISCUSION: The characterization of "cognitive frailty" must be done in frail subjects to set up specific preventive clinical trials for this population.

Indexed as

Alzheimer Diseasecognitive frailtyelderlyMAPT trialphysical frailty

Identifiers

PMID27547746
PMCPMC4991881

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.