Evidence map›Paper›PMID 27547728›Full record

ArticleNeuroImage. Clinical2016

Functional near infrared spectroscopy as a probe of brain function in people with prolonged disorders of consciousness.

Agnieszka M Kempny, Leon James, Kudret Yelden, Sophie Duport, Simon Farmer, E Diane Playford, Alexander P Leff

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage. Clinical, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 66 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Agnieszka M KempnyThe Institute of Neuro-palliative Rehabilitation, Royal Hospital for Neuro-disability, SW15 3SW London, UK; Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, Queen Square, WC1N 3BG London, UK.
Leon JamesThe Institute of Neuro-palliative Rehabilitation, Royal Hospital for Neuro-disability, SW15 3SW London, UK.
Kudret YeldenThe Institute of Neuro-palliative Rehabilitation, Royal Hospital for Neuro-disability, SW15 3SW London, UK; Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, Queen Square, WC1N 3BG London, UK.
Sophie DuportThe Institute of Neuro-palliative Rehabilitation, Royal Hospital for Neuro-disability, SW15 3SW London, UK.
Simon FarmerThe National Hospital for Neurology & Neurosurgery, Queen Square, London WC1N 3 BG, UK.
E Diane PlayfordThe Institute of Neuro-palliative Rehabilitation, Royal Hospital for Neuro-disability, SW15 3SW London, UK; Department of Brain Repair and Rehabilitation, Institute of Neurology, University College London, Queen Square, WC1N 3BG London, UK.
Alexander P LeffDepartment of Brain Repair and Rehabilitation, Institute of Neurology, University College London, Queen Square, WC1N 3BG London, UK; Institute of Cognitive Neuroscience, University College London, Queen Square, WC1N 3AR London, UK.
Royal Hospital for Neuro-disability · GBNational Hospital for Neurology and Neurosurgery · GBQueen Mary University of London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Near infrared spectroscopy (NIRS) is a non-invasive technique which measures changes in brain tissue oxygenation. NIRS has been used for continuous monitoring of brain oxygenation during medical procedures carrying high risk of iatrogenic brain ischemia and also has been adopted by cognitive neuroscience for studies on executive and cognitive functions. Until now, NIRS has not been used to detect residual cognitive functions in patients with prolonged disorders of consciousness (pDOC). In this study we aimed to evaluate the brain function of patients with pDOC by using a motor imagery task while recording NIRS. We also collected data from a group of age and gender matched healthy controls while they carried out both real and imagined motor movements to command. We studied 16 pDOC patients in total, split into two groups: five had a diagnosis of Vegetative state/Unresponsive Wakefulness State, and eleven had a diagnosis of Minimally Conscious State. In the control subjects we found a greater oxy-haemoglobin (oxyHb) response during real movement compared with imagined movement. For the between group comparison, we found a main effect of hemisphere, with greater depression of oxyHb signal in the right > left hemisphere compared with rest period for all three groups. A post-hoc analysis including only the two pDOC patient groups was also significant suggesting that this effect was not just being driven by the control subjects. This study demonstrates for the first time the feasibility of using NIRS for the assessment of brain function in pDOC patients using a motor imagery task.

Indexed as

Spectroscopy, Near-InfraredAdolescentAdultAgedBrainBrain MappingConsciousness DisordersFemaleFunctional LateralityHumansImaginationMaleMiddle AgedYoung AdultBrain function assessment in disorders of consciousnessfNIRS, functional near infrared spectroscopyFunctional near infrared spectroscopyM1, primary motor cortexMCS, minimally conscious stateMI, motor imageryMM, motor movementpDOC, prolonged disorders of consciousness(Prolonged) disorders of consciousnessSMART, Sensory Modality Assessment for Rehabilitation TechniqueSMA, supplementary motor areaUWS, unresponsive wakefulness stateVS, vegetative state

Identifiers

PMID27547728
PMCPMC4983150
OpenAlexW2500213930

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.