Evidence map›Paper›PMID 27547714›Full record

ArticleSports medicine - open2015

Genomic Integrity Is Favourably Affected by High-Intensity Interval Training in an Animal Model of Early-Stage Chronic Kidney Disease.

Patrick S Tucker, Aaron T Scanlan, Rebecca K Vella, Vincent J Dalbo

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Article in Sports medicine - open, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Patrick S TuckerClinical Biochemistry Laboratory, School of Medical and Applied Sciences, Central Queensland University, Bruce Highway, Building 81, Room 1.11, Rockhampton, 4702 Queensland Australia ; Human Exercise and Training Laboratory, Central Queensland University, Bruce Highway, Building 81, Rockhampton, 4702 Australia.ORCID 0000-0003-4624-4345
Aaron T ScanlanClinical Biochemistry Laboratory, School of Medical and Applied Sciences, Central Queensland University, Bruce Highway, Building 81, Room 1.11, Rockhampton, 4702 Queensland Australia ; Human Exercise and Training Laboratory, Central Queensland University, Bruce Highway, Building 81, Rockhampton, 4702 Australia.
Rebecca K VellaCardiovascular Pharmacology Laboratory, Central Queensland University, Bruce Highway, Building 81, Rockhampton, 4702 Australia.
Vincent J DalboClinical Biochemistry Laboratory, School of Medical and Applied Sciences, Central Queensland University, Bruce Highway, Building 81, Room 1.11, Rockhampton, 4702 Queensland Australia ; Human Exercise and Training Laboratory, Central Queensland University, Bruce Highway, Building 81, Rockhampton, 4702 Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChronic kidney disease (CKD) is an irreversible disease that diminishes length and quality of life. Emerging evidence suggests CKD progression and genomic integrity are inversely and causally related. To reduce health complications related to CKD progression, chronic aerobic exercise is often recommended. To date, appraisals of differing modes of exercise, along with postulations regarding the mechanisms responsible for observed effects, are lacking. In order to examine the ability of aerobic exercise to encourage improvements in genomic integrity, we evaluated the effects of 8 weeks of high-intensity interval training (HIIT; 85 % VO

methodsTo assess genomic integrity, we examined kidney-specific messenger RNA (mRNA) expression of genes related to genomic repair and stability:

resultsFollowing HIIT, mRNA expression of

conclusionsOur results suggest that HIIT is superior to SED and LIT as HIIT beneficially influenced the expression of genes related to genomic integrity.

Identifiers

PMID27547714
PMCPMC4978751

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.