Evidence map›Paper›PMID 27547699›Full record

ArticleCurrent tropical medicine reports2016

For Whom the Bell Tolls (and Nods): Spit-acular Saliva.

Dana K Shaw, Michail Kotsyfakis, Joao H F Pedra

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current tropical medicine reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Ticks: More Than Just a Pathogen Delivery Service.Frontiers in cellular and infection microbiology · 2021
    Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Dana K ShawDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA. .
Michail KotsyfakisInstitute of Parasitology, Biology Centre, Czech Academy of Sciences, Budweis, Czech Republic.
Joao H F PedraDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA. .

Funding

Ubiquitylation and Rickettsial Colonization of a Tick VectorR01AI116523 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI PEDRA, JOAO · 2016 to 2025
$6.2M
Rickettsial Immunity During Tick TransmissionR01AI093653 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI PEDRA, JOAO · 2011 to 2015
$1.8M
NIAID NIH HHS R01 AI093653NIAID NIH HHS R01 AI116523
6 · The paper itself

Abstract

Having emerged during the early part of the Cretaceous period, ticks are an ancient group of hematophagous ectoparasites with significant veterinary and public health importance worldwide. The success of their life strategy can be attributed, in part, to saliva. As we enter into a scientific era where the collection of massive data sets and structures for biological application is possible, we suggest that understanding the molecular mechanisms that govern the life cycle of ticks is within grasp. With this in mind, we discuss what is currently known regarding the manipulation of Toll-like (TLR) and Nod-like (NLR) receptor signaling pathways by tick salivary proteins, and how these molecules impact pathogen transmission.

Indexed as

Innate immune signalingNod-like receptors (NLR)Tick-borne diseasesTick salivaToll-like receptors (TLR)

Identifiers

PMID27547699
PMCPMC4987094

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.