Evidence map›Paper›PMID 27547635›Full record

ReviewChemistryOpen2016

"Rules of Engagement" of Protein-Glycoconjugate Interactions: A Molecular View Achievable by using NMR Spectroscopy and Molecular Modeling.

Roberta Marchetti, Serge Perez, Ana Arda, Anne Imberty, Jesus Jimenez-Barbero, Alba Silipo, Antonio Molinaro

Abstract readReview
In one paragraph

Review in ChemistryOpen, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

  1. A multifunctional anti-O-Antigen human monoclonal antibody protects againstProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Molecular recognition ofiScience · 2024
    Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Recent Advances in the Chemical Biology ofMolecules (Basel, Switzerland) · 2021
    Review
  12. Article
  13. Article
  14. Carbohydrate-Protein Interactions: Advances and Challenges.Communications in information and systems · 2021
    Article
  15. Article
  16. Three-Dimensional Structures of Carbohydrates and Where to Find Them.International journal of molecular sciences · 2020
    Review
  17. Conformational Studies of Oligosaccharides.Chemistry (Weinheim an der Bergstrasse, Germany) · 2020
    Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Roberta MarchettiDepartment of Chemical Sciencest University of Napoli Federico II Via Cintia 4 80126 Napoli Italy.
Serge PerezDepartment Molecular Pharmacochemistry UMR 5063 CNRS and University of Grenoble Alpes, BP 53 38041 Grenoble cedex 9 France.
Ana ArdaBizkaia Technological Park CIC bioGUNE Building 801A-1 48160 Derio-Bizkaia Spain.
Anne ImbertyCentre de Recherche sur les CNRS and University of Grenoble Macromolécules Végétales, UPR 5301 Alpes, BP 53 38041 Grenoble cedex 9 France.
Jesus Jimenez-BarberoBizkaia Technological Park CIC bioGUNE Building 801A-1 48160 Derio-Bizkaia Spain.
Alba SilipoDepartment of Chemical Sciencest University of Napoli Federico II Via Cintia 4 80126 Napoli Italy.
Antonio MolinaroDepartment of Chemical Sciencest University of Napoli Federico II Via Cintia 4 80126 Napoli Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Understanding the dynamics of protein-ligand interactions, which lie at the heart of host-pathogen recognition, represents a crucial step to clarify the molecular determinants implicated in binding events, as well as to optimize the design of new molecules with therapeutic aims. Over the last decade, advances in complementary biophysical and spectroscopic methods permitted us to deeply dissect the fine structural details of biologically relevant molecular recognition processes with high resolution. This Review focuses on the development and use of modern nuclear magnetic resonance (NMR) techniques to dissect binding events. These spectroscopic methods, complementing X-ray crystallography and molecular modeling methodologies, will be taken into account as indispensable tools to provide a complete picture of protein-glycoconjugate binding mechanisms related to biomedicine applications against infectious diseases.

Indexed as

glycoconjugatesmolecular modelingmolecular recognitionNMR spectroscopyproteins

Identifiers

PMID27547635
PMCPMC4981046

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.