Evidence map›Paper›PMID 27547558›Full record

ArticlePeerJ2016

Simultaneous bilateral laser therapy accelerates recovery after noise-induced hearing loss in a rat model.

Jae-Hun Lee, So-Young Chang, Wesley J Moy, Connie Oh, Se-Hyung Kim, Chung-Ku Rhee, Jin-Chul Ahn, Phil-Sang Chung, Jae Yun Jung, Min Young Lee

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Jae-Hun LeeCollege of Medicine, Dankook University, Beckman Laser Institute Korea , Cheonan , South Korea.
So-Young ChangCollege of Medicine, Dankook University, Beckman Laser Institute Korea , Cheonan , South Korea.
Wesley J MoyBeckman Laser Institute and Medical Clinic, University of California , Irvine , CA , United States.
Connie OhBeckman Laser Institute and Medical Clinic, University of California , Irvine , CA , United States.
Se-Hyung KimDepartment of Otolaryngology-Head and Neck Surgery, Jeju National University School of Medicine , Jeju , South Korea.
Chung-Ku RheeDepartment of Otolaryngology-Head & Neck Surgery, College of Medicine, Dankook University , Cheonan , South Korea.
Jin-Chul AhnDepartment of Biomedical Science, College of Medicine, Dankook University , Cheonan , South Korea.
Phil-Sang ChungCollege of Medicine, Dankook University, Beckman Laser Institute Korea, Cheonan, South Korea; Department of Otolaryngology-Head & Neck Surgery, College of Medicine, Dankook University, Cheonan, South Korea.
Jae Yun JungCollege of Medicine, Dankook University, Beckman Laser Institute Korea, Cheonan, South Korea; Department of Otolaryngology-Head & Neck Surgery, College of Medicine, Dankook University, Cheonan, South Korea.
Min Young LeeDepartment of Otolaryngology-Head & Neck Surgery, College of Medicine, Dankook University , Cheonan , South Korea.
Dankook University · KRBeckman Laser Institute and Medical Clinic · USJeju National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Noise-induced hearing loss is a common type of hearing loss. The effects of laser therapy have been investigated from various perspectives, including in wound healing, inflammation reduction, and nerve regeneration, as well as in hearing research. A promising feature of the laser is its capability to penetrate soft tissue; depending on the wavelength, laser energy can penetrate into the deepest part of the body without damaging non-target soft tissues. Based on this idea, we developed bilateral transtympanic laser therapy, which uses simultaneous laser irradiation in both ears, and evaluated the effects of bilateral laser therapy on cochlear damage caused by noise overexposure. Thus, the purpose of this research was to assess the benefits of simultaneous bilateral laser therapy compared with unilateral laser therapy and a control. Eighteen Sprague-Dawley rats were exposed to narrow-band noise at 115 dB SPL for 6 h. Multiple auditory brainstem responses were measured after each laser irradiation, and cochlear hair cells were counted after the 15th such irradiation. The penetration depth of the 808 nm laser was also measured after sacrifice. Approximately 5% of the laser energy reached the contralateral cochlea. Both bilateral and unilateral laser therapy decreased the hearing threshold after noise overstimulation in the rat model. The bilateral laser therapy group showed faster functional recovery at all tested frequencies compared with the unilateral laser therapy group. However, there was no difference in the endpoint ABR results or final hair cell survival, which was analyzed histologically.

Indexed as

ABRBilateral LLLTHair cell survivalNoise induced hearing loss

Identifiers

PMID27547558
PMCPMC4963219
OpenAlexW2475419833

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.