ArticlePeerJ2016
Computational fluid dynamics modelling of left valvular heart diseases during atrial fibrillation.
Article in PeerJ, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Effects of Ageing on Aortic Circulation During Atrial Fibrillation; a Numerical Study on Different Aortic Morphologies.Annals of biomedical engineering · 2021Pooled it
- Patient-Specific Analysis of Ventricular Vortex Formation and Flow Energetics in Rheumatic and Calcific Mitral Stenosis.Annals of biomedical engineering · 2026Article
- Incidental Right Atrial Appendage Thrombosis in a Patient With a Left Atrial Appendage Occlusion Device.JACC. Case reports · 2026Article
- Computational modelling of valvular heart disease: haemodynamic insights and clinical implications.Frontiers in bioengineering and biotechnology · 2024Review
- Impact of Concomitant Mitral Regurgitation on the Hemodynamic Indicators of Aortic Stenosis.Journal of the American Heart Association · 2023Article
- Cerebral hemodynamics during atrial fibrillation: Computational fluid dynamics analysis of lenticulostriate arteries using 7 T high-resolution magnetic resonance imaging.Physics of fluids (Woodbury, N.Y. : 1994) · 2022Article
- Insights from computational modeling on the potential hemodynamic effects of sinus rhythm versus atrial fibrillation.Frontiers in cardiovascular medicine · 2022Review
- Different Impact of Heart Rate Variability in the Deep Cerebral and Central Hemodynamics at Rest: AnFrontiers in neuroscience · 2021Article
- Numerical Study of Atrial Fibrillation Effects on Flow Distribution in Aortic Circulation.Annals of biomedical engineering · 2020Article
- Left Atrial Function after Atrial Fibrillation Cryoablation Concomitant to Minimally Invasive Mitral Valve Repair: A Pilot Study on Long-Term Results and Clinical Implications.Medicina (Kaunas, Lithuania) · 2019Article
- Higher ventricular rate during atrial fibrillation relates to increased cerebral hypoperfusions and hypertensive events.Scientific reports · 2019Article
- The impact of cardiac rhythm on the mitral valve area and gradient in patients with mitral stenosis.Anatolian journal of cardiology · 2017Article
- Alteration of cerebrovascular haemodynamic patterns due to atrial fibrillation: anJournal of the Royal Society, Interface · 2017Article
- A Computational Study on the Relation between Resting Heart Rate and Atrial Fibrillation Hemodynamics under Exercise.PloS one · 2017Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough atrial fibrillation (AF), a common arrhythmia, frequently presents in patients with underlying valvular disease, its hemodynamic contributions are not fully understood. The present work aimed to computationally study how physical conditions imposed by pathologic valvular anatomy act on AF hemodynamics.
methodsWe simulated AF with different severity grades of left-sided valvular diseases and compared the cardiovascular effects that they exert during AF, compared to lone AF. The fluid dynamics model used here has been recently validated for lone AF and relies on a lumped parameterization of the four heart chambers, together with the systemic and pulmonary circulation. The AF modelling involves: (i) irregular, uncorrelated and faster heart rate; (ii) atrial contractility dysfunction. Three different grades of severity (mild, moderate, severe) were analyzed for each of the four valvulopathies (AS, aortic stenosis, MS, mitral stenosis, AR, aortic regurgitation, MR, mitral regurgitation), by varying-through the valve opening angle-the valve area.
resultsRegurgitation was hemodynamically more relevant than stenosis, as the latter led to inefficient cardiac flow, while the former introduced more drastic fluid dynamics variation. Moreover, mitral valvulopathies were more significant than aortic ones. In case of aortic valve diseases, proper mitral functioning damps out changes at atrial and pulmonary levels. In the case of mitral valvulopathy, the mitral valve lost its regulating capability, thus hemodynamic variations almost equally affected regions upstream and downstream of the valve. In particular, the present study revealed that both mitral and aortic regurgitation strongly affect hemodynamics, followed by mitral stenosis, while aortic stenosis has the least impact among the analyzed valvular diseases. DISCUSSION: The proposed approach can provide new mechanistic insights as to which valvular pathologies merit more aggressive treatment of AF. Present findings, if clinically confirmed, hold the potential to impact AF management (e.g., adoption of a rhythm control strategy) in specific valvular diseases.
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