ArticlePeerJ2016
Transcriptome analysis of Pseudomonas aeruginosa PAO1 grown at both body and elevated temperatures.
Article in PeerJ, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
- The interplay between temperature and growth phase shapes the transcriptional landscape ofJournal of bacteriology · 2026Article
- Mechanisms of thermoregulation inJournal of bacteriology · 2026Review
- Function and transcription of the lon gene in Xanthomonas campestris pv. campestris.Antonie van Leeuwenhoek · 2025Article
- TheInternational journal of molecular sciences · 2023Article
- Transcriptional analysis in bacteriophage Fc02 ofFrontiers in microbiology · 2023Article
- Cell Envelope Stress Response in Pseudomonas aeruginosa.Advances in experimental medicine and biology · 2022Article
- New insights about the EptA protein and its correlation with theCurrent research in microbial sciences · 2021Article
- Article
- Genome-Wide Analyses of the Temperature-Responsive Genetic Loci of the Pectinolytic Plant PathogenicInternational journal of molecular sciences · 2021Article
- LeveragingFrontiers in microbiology · 2021Review
- Transcriptomic determinants of the response of ST-111 Pseudomonas aeruginosa AG1 to ciprofloxacin identified by a top-down systems biology approach.Scientific reports · 2020Article
- Mobile Genetic Elements in Pseudomonas stutzeri.Current microbiology · 2020Article
- The Temperature-Regulation ofFrontiers in microbiology · 2020Article
- RNA-Seq-Based Comparative Transcriptome Analysis Highlights New Features of the Heat-Stress Response in the Extremophilic BacteriumInternational journal of molecular sciences · 2019Article
- Combined transcriptomics-metabolomics profiling of the heat shock response in the hyperthermophilic archaeon Pyrococcus furiosus.Extremophiles : life under extreme conditions · 2019Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Functional genomics research can give us valuable insights into bacterial gene function. RNA Sequencing (RNA-seq) can generate information on transcript abundance in bacteria following abiotic stress treatments. In this study, we used the RNA-seq technique to study the transcriptomes of the opportunistic nosocomial pathogen Pseudomonas aeruginosa PAO1 following heat shock. Samples were grown at both the human body temperature (37 °C) and an arbitrarily-selected temperature of 46 °C. In this work using RNA-seq, we identified 133 genes that are differentially expressed at 46 °C compared to the human body temperature. Our work identifies some key P. aeruginosa PAO1 genes whose products have importance in both environmental adaptation as well as in vivo infection in febrile hosts. More importantly, our transcriptomic results show that many genes are only expressed when subjected to heat shock. Because the RNA-seq can generate high throughput gene expression profiles, our work reveals many unanticipated genes with further work to be done exploring such genes products.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.