Evidence map›Paper›PMID 27547530›Full record

ArticlePeerJ2016

Morphological analysis of dendrites and spines by hybridization of ridge detection with twin support vector machine.

Shuihua Wang, Mengmeng Chen, Yang Li, Ying Shao, Yudong Zhang, Sidan Du, Jane Wu

Open access · goldAbstract read
In one paragraph

Article in PeerJ, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Shuihua WangSchool of Electronic Science and Engineering, Nanjing University, Jiangsu, China; School of Computer Science and Technology, Nanjing Normal University, Nanjing, Jiangsu, China.
Mengmeng ChenDepartment of Neurology, Northwestern University School of Medicine, Chicago, USA; State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Yang LiSchool of Electronic Science and Engineering, Nanjing University , Jiangsu , China.
Ying ShaoSchool of Psychology, Nanjing Normal University , Nanjing, Jiangsu , China.
Yudong ZhangSchool of Computer Science and Technology, Nanjing Normal University , Nanjing , Jiangsu , China.
Sidan DuSchool of Electronic Science and Engineering, Nanjing University , Jiangsu , China.
Jane WuSchool of Electronic Science and Engineering, Nanjing University, Jiangsu, China; Department of Neurology, Northwestern University School of Medicine, Chicago, USA; State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Nanjing Normal University · CNNanjing University · CNNorthwestern University · US

Funding

The role of deubiquitinating enzyme USP33 in Slit-Robo signaling in lung cancerR01CA175360 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI WU, JANE Y · 2014 to 2018
$2.2M
Mechanisms regulating tau alternative pre-mRNA splicingR01AG033004 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI WU, JANE Y · 2011 to 2015
$1.5M
NCI NIH HHS R01 CA175360NIA NIH HHS R01 AG033004
6 · The paper itself

Abstract

Dendritic spines are described as neuronal protrusions. The morphology of dendritic spines and dendrites has a strong relationship to its function, as well as playing an important role in understanding brain function. Quantitative analysis of dendrites and dendritic spines is essential to an understanding of the formation and function of the nervous system. However, highly efficient tools for the quantitative analysis of dendrites and dendritic spines are currently undeveloped. In this paper we propose a novel three-step cascaded algorithm-RTSVM- which is composed of ridge detection as the curvature structure identifier for backbone extraction, boundary location based on differences in density, the Hu moment as features and Twin Support Vector Machine (TSVM) classifiers for spine classification. Our data demonstrates that this newly developed algorithm has performed better than other available techniques used to detect accuracy and false alarm rates. This algorithm will be used effectively in neuroscience research.

Indexed as

Dendritic spineNeuronRidgelet detectionTwin Support vector machine

Identifiers

PMID27547530
PMCPMC4958009
OpenAlexW2485782123

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.