Evidence map›Paper›PMID 27547493›Full record

ArticleACS macro letters2016

Block Copolymer Membranes for Efficient Capture of a Chemotherapy Drug.

X Chelsea Chen, Hee Jeung Oh, Jay F Yu, Jeffrey K Yang, Nikos Petzetakis, Anand S Patel, Steven W Hetts, Nitash P Balsara

Abstract read
In one paragraph

Article in ACS macro letters, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. 3D Printed Biosponge Adsorbers for Capturing Toxic Chemotherapy DrugsACS biomaterials science & engineering · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. A two-scale approach for CFD modeling of endovascular Chemofilter device.Biomechanics and modeling in mechanobiology · 2018
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

X Chelsea ChenMaterials Sciences Division and Energy Technologies Area, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States; Department of Chemical and Biomolecular Engineering, University of California-Berkeley, Berkeley, California 94720, United States.
Hee Jeung OhDepartment of Chemical and Biomolecular Engineering, University of California-Berkeley , Berkeley, California 94720, United States.
Jay F YuDepartment of Radiology and Biomedical Imaging, University of California-San Francisco , San Francisco, California 94107, United States.
Jeffrey K YangDepartment of Radiology and Biomedical Imaging, University of California-San Francisco , San Francisco, California 94107, United States.
Nikos PetzetakisDepartment of Chemical and Biomolecular Engineering, University of California-Berkeley , Berkeley, California 94720, United States.
Anand S PatelDepartment of Radiology and Biomedical Imaging, University of California-San Francisco , San Francisco, California 94107, United States.
Steven W HettsDepartment of Radiology and Biomedical Imaging, University of California-San Francisco , San Francisco, California 94107, United States.
Nitash P BalsaraMaterials Sciences Division and Energy Technologies Area, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States; Department of Chemical and Biomolecular Engineering, University of California-Berkeley, Berkeley, California 94720, United States; Materials Sciences Division and Energy Technologies Area, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.

Funding

Endovascular Chemofiltration: Optimizing Removal of Chemotherapeutics and Nanoparticles from the Blood to Reduce ToxicityR01CA194533 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HETTS, STEVEN WILLIAM · 2015 to 2019
$2.6M
ChemoFilter: A Novel Catheter Device to Enable High-Dose Chemotherapy TreatmentR41CA183327 · NCI · CHEMOFILTER, INC. · PI PATEL, ANAND S · 2014 to 2014
$225k
NCI NIH HHS R01 CA194533NCI NIH HHS R41 CA183327
6 · The paper itself

Abstract

We introduce the use of block copolymer membranes for an emerging application, "drug capture". The polymer is incorporated in a new class of biomedical devices, referred to as ChemoFilter, which is an image-guided temporarily deployable endovascular device designed to increase the efficacy of chemotherapy-based cancer treatment. We show that block copolymer membranes consisting of functional sulfonated polystyrene end blocks and a structural polyethylene middle block (S-SES) are capable of capturing doxorubicin, a chemotherapy drug. We focus on the relationship between morphology of the membrane in the ChemoFilter device and efficacy of doxorubicin capture measured in vitro. Using small-angle X-ray scattering and cryogenic scanning transmission electron microscopy, we discovered that rapid doxorubicin capture is associated with the presence of water-rich channels in the lamellar-forming S-SES membranes in aqueous environment.

Identifiers

PMID27547493
PMCPMC4989249

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.