ReviewOpen heart
Added sugars drive nutrient and energy deficit in obesity: a new paradigm.
Review in Open heart. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Sugar Reduction Initiatives in the Eastern Mediterranean Region: A Systematic Review.Nutrients · 2022Pooled it
- Trading too much sugar for too much salt? How a well-designed dietary intervention trial to reduce added sugar intake among children produced some answers and many questions.The American journal of clinical nutrition · 2026Article
- Myo-inositol supplementation in gestational diabetes mellitus: is there any interference with diet?Frontiers in nutrition · 2025Article
- Association between dietary nutrient intake and sleep disorders in hypertensive patients: a cross-sectional study of NHANES, 2005-2020.Frontiers in nutrition · 2025Article
- Technology adaptation in sugarcane supply chain based on a novel p, q Quasirung Orthopair Fuzzy decision making framework.Scientific reports · 2024Article
- Maternal Mediterranean Diet During Lactation and Infant Growth.Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine · 2024Observational
- Review
- Nutritional Deficiencies and Associated Oral Health in Adolescents: A Comprehensive Scoping Review.Children (Basel, Switzerland) · 2024Article
- Association between plant-based diet quality and chronic kidney disease in Australian adults.Public health nutrition · 2024Article
- Sucrose overconsumption impairs AgRP neuron dynamics and promotes palatable food intake.Cell reports · 2024Article
- Association of all-cause mortality with sugar intake from different sources in the prospective cohort of UK Biobank participants.The British journal of nutrition · 2023Article
- Dynamic changes in hepatic DNA methylation during the development of nonalcoholic fatty liver disease induced by a high-sugar diet.Journal of physiology and biochemistry · 2022Article
- Maternal Fructose Intake, Programmed Mitochondrial Function and Predisposition to Adult Disease.International journal of molecular sciences · 2022Review
- Beneficial Effects of Tamarind Trypsin Inhibitor in Chitosan-Whey Protein Nanoparticles on Hepatic Injury Induced High Glycemic Index Diet: A Preclinical Study.International journal of molecular sciences · 2021Article
- Explaining the Black-White Disparity in Preterm Birth: A Consensus Statement From a Multi-Disciplinary Scientific Work Group Convened by the March of Dimes.Frontiers in reproductive health · 2021Review
- Lycopene Modulates Pathophysiological Processes of Non-Alcoholic Fatty Liver Disease in Obese Rats.Antioxidants (Basel, Switzerland) · 2019Article
- Review
- Drug-Induced Mitochondrial Toxicity in the Geriatric Population: Challenges and Future Directions.Biology · 2019Review
- Diet-dependence of metabolic perturbations mediated by the endocrine disruptor tolylfluanid.Endocrine connections · 2018Article
- Diet-driven microbiota dysbiosis is associated with vagal remodeling and obesity.Physiology & behavior · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obesity has traditionally been thought of as a state of caloric imbalance, where the intake of calories exceeds the expenditure or 'burning' of calories. However, a more nuanced appreciation for the complex biochemistry and physiology of cellular energy generation suggests that obesity is a state of hormonal imbalance causing increased shunting of food energy into adipose tissue for storage, resulting in decreased satiety and ultimately leading to increased caloric intake. Adding to this hypothesis, we propose that obesity is also a state of nutrient and energy deficit, leading to decreased fatty acid mobilisation and oxidation, the result of which may be a natural disinclination towards physical activity. Added sugars (sucrose, a.k.a. table sugar and high-fructose corn syrup) may provide energy (4 kcal/g) but at current intakes they do not facilitate-and may even hinder-the production of energy. Not only do added sugars displace nutritionally superior foods in the diet, but they may also deplete nutrients from other foods that have been consumed, as well as from body stores, in order to enable their proper oxidation and liberate their calories as energy. Additionally, the consumption of added sugars damages the mitochondria and hence impairs energy generation. Moreover, overconsuming added sugars may result in a kind of 'internal starvation' (via leptin and insulin resistance) leading to further hunger signals in the body. Added sugars promote nutrient and energy deficit and through this novel pathway promote obesity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.