ArticleBMJ open respiratory research2016
Comprehensive evidence-based review on European antitussives.
Article in BMJ open respiratory research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 86 citations in OpenAlex.
- Diagnosis and Treatment of Adult Patients with Cough.Respiration; international review of thoracic diseases · 2025Guideline
- Effect of Jiuwei Zhuhuang Powder on Cough Resolution in Children with Upper Respiratory Tract Infections: A Multicenter Randomized Controlled Trial.Chinese journal of integrative medicine · 2022Trial
- Traditional Chinese medicine combined with conventional Western medicine for chronic cough following respiratory infection in children: a systematic review and meta-analysis.Translational pediatrics · 2026Article
- An Epidemiological Study on the Effectiveness of Nasturtium Herb and Horseradish Root (AngocinAntibiotics (Basel, Switzerland) · 2026Article
- Expert opinion and clinical practice recommendations using a modified Delphi approach for pediatric acute cough evaluation and management in India.Lung India : official organ of Indian Chest Society · 2026Article
- Expert Opinion: A Call for Early and Appropriate Symptomatic Treatment in Acute Respiratory Infections to Prevent Escalation.Healthcare (Basel, Switzerland) · 2025Article
- Efficacy and Safety of a Single Ivy Extract Versus Two Herbal Extract Combinations in Patients with Acute Bronchitis: A Multi-Center, Randomized, Open-Label Clinical Trial.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Neuromodulators in Acute and Chronic Cough in Children: An Update from the Literature.International journal of molecular sciences · 2024Review
- The validity of single-item measures of health-related quality of life across groups differing in acute respiratory symptom severity.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024Article
- Prescription patterns and symptom relief of antitussives and expectorants in patients with cough: a nationwide study in Korea.Journal of thoracic disease · 2024Article
- A Review of Wastewater-Based Epidemiology Studies for the Assessment of Over-the-Counter Medicines Used as Recreational Drugs: The Example of Dextromethorphan.Medical science monitor : international medical journal of experimental and clinical research · 2024Review
- Potential Saving of Antibiotics for Respiratory Infections in Several European Countries: Insights from Market Research Data.Antibiotics (Basel, Switzerland) · 2023Article
- The treatment of mild upper respiratory tract infections - a position paper with recommendations for best practice.Drugs in context · 2023Review
- Risk factors contributing to impaired cough-specific quality of life at the time of admission for coronavirus disease 2019 treatment.Journal of thoracic disease · 2022Article
- Effects of Pelargonium sidoides extract EPs 7630 on acute cough and quality of life - a meta-analysis of randomized, placebo-controlled trials.Multidisciplinary respiratory medicine · 2022Article
- History Taking as a Diagnostic Tool in Children With Chronic Cough.Frontiers in pediatrics · 2022Review
- Liver Involvement in Acute Respiratory Infections in Children and Adolescents - Results of a Non-interventional Study.Frontiers in pediatrics · 2022Article
- Appropriate use of essential oils and their components in the management of upper respiratory tract symptoms in patients with COVID-19.Journal of herbal medicine · 2021Review
- Paediatric outpatient prescriptions in France between 2010 and 2019: A nationwide population-based study: Paediatric outpatient prescriptions in France, 2010 to 2019.The Lancet regional health. Europe · 2021Article
- Impact of guideline awareness on the counseling of patients with acute cough among general practitioners and pharmacy personnel.PloS one · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute cough caused by viral respiratory tract infections is probably the most common illness to afflict mankind. Despite the widespread but ineffective prescribing of antibiotics, there is no specific therapy. Home remedies and over-the-counter medicines are the mainstay for treatment of this short-lived but debilitating condition where cough is a major troublesome symptom. Across Europe, there are large variations in the recommendations made by healthcare professionals for the treatment of acute cough. This has arisen through custom and practice based on the evidence of historical studies performed to standards well short of what would be considered legitimate today. Acute cough is particularly difficult to study in a controlled setting because of the high rate of spontaneous remission and a large placebo effect. Here we detail the validated modern methodology used to assess the efficacy of antitussives and review the drugs commonly used in Europe against these standards.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.