ArticleFrontiers in psychology2016
Brain Activity in Response to Trauma-specific, Negative, and Neutral Stimuli. A fMRI Study of Recent Road Traffic Accident Survivors.
Article in Frontiers in psychology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Post-Traumatic Stress Disorder (PTSD) Resulting from Road Traffic Accidents (RTA): A Systematic Literature Review.International journal of environmental research and public health · 2025Pooled it
- Resting-State Functional Connectivity Changes Associated With Post-Traumatic Stress and Anxiety Symptoms in North Korean Refugees.Psychiatry investigation · 2026Article
- Functional connectivity profiles of amygdala subregions in posttraumatic stress disorder.Translational psychiatry · 2025Article
- Prior Sexual Trauma Exposure Impacts Posttraumatic Dysfunction and Neural Circuitry Following a Recent Traumatic Event in the AURORA Study.Biological psychiatry global open science · 2023Article
- Structural brain correlates of childhood trauma with replication across two large, independent community-based samples.European psychiatry : the journal of the Association of European Psychiatrists · 2023Article
- A tale of two targets: examining the differential effects of posterior cingulate cortex- and amygdala-targeted fMRI-neurofeedback in a PTSD pilot study.Frontiers in neuroscience · 2023Article
- Effects of stress on neural processing of combat-related stimuli in deployed soldiers: an fMRI study.Translational psychiatry · 2022Article
- Neighborhood Socioeconomic Disadvantage and the Neurobiology of Uncertainty in Traumatically Injured Adults.Biological psychiatry global open science · 2022Article
- Differential mechanisms of posterior cingulate cortex downregulation and symptom decreases in posttraumatic stress disorder and healthy individuals using real-time fMRI neurofeedback.Brain and behavior · 2022Article
- Neural contributors to trauma resilience: a review of longitudinal neuroimaging studies.Translational psychiatry · 2021Review
- Abnormal Functional Connectivity of the Amygdala in Mild Cognitive Impairment Patients With Depression Symptoms Revealed by Resting-State fMRI.Frontiers in psychiatry · 2021Article
- Multi-voxel pattern analysis of amygdala functional connectivity at rest predicts variability in posttraumatic stress severity.Brain and behavior · 2020Article
- Amygdala functional connectivity in the acute aftermath of trauma prospectively predicts severity of posttraumatic stress symptoms.Neurobiology of stress · 2020Article
- Article
- Assault-related self-blame and its association with PTSD in sexually assaulted women: an MRI inquiry.Social cognitive and affective neuroscience · 2018Article
- Neurocognitive, emotional and neuroendocrine correlates of exposure to sexual assault in women.Journal of psychiatry & neuroscience : JPN · 2018Article
- Functional Neuroanatomy of Emotion and Its Regulation in PTSD.Harvard review of psychiatryReview
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most studies of neuro-functional patterns in trauma-exposed individuals have been conducted considerable time after the traumatic event. Hence little is known about neuro-functional processing shortly after trauma-exposure. We investigated brain activity patterns in response to trauma reminders as well as neutral and negative stimuli in individuals who had recently (within 3 weeks) been involved in a road traffic accident (RTA). Twenty-three RTA survivors and 17 non-trauma-exposed healthy controls (HCs) underwent functional MRI while viewing Trauma-specific, Negative, and Neutral pictures. Data were analyzed from four a priori regions of interest, including bilateral amygdala, subcallosal cortex, and medial prefrontal cortex. In addition, we performed a whole brain analysis and functional connectivity analysis during stimulus presentation. For both groups, Negative stimuli elicited more activity in the amygdala bilaterally than did Neutral and Trauma-specific stimuli. The whole brain analysis revealed higher activation in sensory processing related areas (bilateral occipital and temporal cortices and thalamus) as well as frontal and superior parietal areas, for the RTA group compared to HC, for Trauma-specific stimuli contrasted with Neutral stimuli. We also observed higher functional connectivity for Trauma-specific stimuli, between bilateral amygdala and somatosensory areas, for the RTA group compared to controls, when contrasted with Neutral stimuli. We argue that these results might indicate an attentional sensory processing bias toward Trauma-specific stimuli for trauma exposed individuals, a result in line with findings from the post-traumatic stress disorder literature.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.