Evidence map›Paper›PMID 27547175›Full record

ArticleTobacco induced diseases2016

Immediate effects of cigar smoking on respiratory mechanics and exhaled biomarkers; differences between young smokers with mild asthma and otherwise healthy young smokers.

Andreas S Lappas, Efstathia M Konstantinidi, Anna S Tzortzi, Chara K Tzavara, Panagiotis K Behrakis

Abstract read
In one paragraph

Article in Tobacco induced diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Biomarkers of Exposure among U.S. Adult Cigar Smokers: Population Assessment of Tobacco and Health (PATH) Study Wave 1 (2013-2014).Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2019
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Andreas S LappasGeorge D Behrakis Research Lab, Hellenic Cancer Society, 8 Doryleou Str, P.C. 11521 Athens, Greece ; Biomedical Research Foundation, Academy of Athens, Athens, Greece.
Efstathia M KonstantinidiGeorge D Behrakis Research Lab, Hellenic Cancer Society, 8 Doryleou Str, P.C. 11521 Athens, Greece ; Biomedical Research Foundation, Academy of Athens, Athens, Greece.
Anna S TzortziGeorge D Behrakis Research Lab, Hellenic Cancer Society, 8 Doryleou Str, P.C. 11521 Athens, Greece ; Institute of Public Health, American College of Greece, Athens, Greece.
Chara K TzavaraDepartment of hygiene, epidemiology and medical statistics, National and Kapodistrian University of Athens, Medical School, Athens, Greece.
Panagiotis K BehrakisGeorge D Behrakis Research Lab, Hellenic Cancer Society, 8 Doryleou Str, P.C. 11521 Athens, Greece ; Biomedical Research Foundation, Academy of Athens, Athens, Greece ; Institute of Public Health, American College of Greece, Athens, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe aimed to investigate the immediate respiratory effects of cigar smoking(CS), among young smokers with and without mild asthma. MATERIALS AND

methodsForty-seven young smokers (18-31years old, 29 males, average pack-years = 3.6 ± 2.8) were enrolled. Twenty-two were mild asthmatics(MA-subgroup) and the remaining 25 were otherwise healthy smokers(HS-subgroup). Exhaled carbon monoxide(eCO), multi-frequency respiratory system impedance(Z), resistance(R), reactance(X), frequency-dependence of resistance(fdr = R5Hz - R20Hz), resonant frequency(fres), reactance area(AX) and exhaled nitric oxide(FENO) were measured at the aforementioned sequence, before and immediately after 30 min of CS, or equal session in the smoking area while using a sham cigar(control group). Chi-square, student's t-tests, mixed linear models and Pearson correlation tests were used for the statistical analysis; level of significance was defined as p < 0.05.

resultsImmediately after CS, Z5Hz, R5Hz, R10Hz, R20Hz and eCO increased significantly in both subgroups(MA and HS). A greater increase was found for R20 in HS-subgroup. Fdr, fres and AX increased in MA, while decreased in HS. On the contrary, X10 decreased in MA and increased in HS, while X20 showed a greater decrease in MA. Changes in fdr, fres and AX were significantly correlated in both subgroups. No significant FENO alterations were detected in both subgroups.

conclusionCS has immediate effects on pulmonary function. Mild asthma predisposes to higher increase of peripheral resistance(increased fdr). In otherwise healthy smokers, central resistance(R20Hz) is more affected. FENO levels are not significantly affected by CS.

Identifiers

PMID27547175
PMCPMC4990845

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.