Evidence map›Paper›PMID 27547173›Full record

ArticleAddiction research & theory

Depressive symptoms affect changes in nicotine withdrawal and smoking urges throughout smoking cessation treatment: Preliminary results.

Holly H Reid, David M Ledgerwood

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Addiction research & theory. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05386862 (Wayne Warrior CAnnabis Research and Education), which is not on this map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05386862 nawithdrawnnot on this map

Wayne Warrior CAnnabis Research and Education: Naturalistic Observation and Harm Reduction

TypeinterventionalSponsorWayne State UniversityRan2022 to 2024Enrolled0ConditionsPost Traumatic Stress Disorder, Cannabis Use, SuicideArmsReduce THC Use
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Predictors of Nicotine Replacement Therapy Adherence: Mixed-Methods Research With a Convergent Parallel Design.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2024
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  10. Potential Moderating Effects of Psychiatric Diagnosis and Symptom Severity on Subjective and Behavioral Responses to Reduced Nicotine Content Cigarettes.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2019
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Holly H ReidDepartment of Psychology, Wayne State University, Detroit, MI, USA; Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, MI, USA.
David M LedgerwoodDepartment of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, MI, USA.
Wayne State University · US

Funding

Prize Reinforcement for Smoking CessationR21DA021839 · NIDA · WAYNE STATE UNIVERSITY · PI LEDGERWOOD, DAVID M · 2007 to 2008
$410k
NIDA NIH HHS R21 DA021839
6 · The paper itself

Abstract

backgroundIndividuals who report more depressive symptoms consistently demonstrate higher rates of nicotine dependence and less successful smoking cessation than do individuals who report fewer depressive symptoms. Nicotine withdrawal and smoking urges are two potential factors that may account for the differences observed between these two groups. This study assessed whether elevated depression symptoms among nicotine dependent smokers are associated with changes in withdrawal and urges to smoke when undergoing smoking cessation treatment.

methodData on 81 nicotine dependent smokers were collected as part of a smoking cessation randomized trial that compared standard and contingency management treatment across one baseline week and four treatment weeks. Linear mixed model analyses were conducted with high and low depression scores predicting changes in withdrawal and urge ratings from a baseline week and four treatment weeks.

resultsParticipants with elevated depression symptoms reported more intense nicotine withdrawal and smoking urges throughout treatment. Further, participants with greater depressive symptoms exhibited an increase in smoking urges at the start of treatment, compared with a gradual decline in urges among participants with fewer depressive symptoms.

conclusionsSmokers with elevated depressive symptoms experience significantly elevated discomfort during smoking cessation efforts in the form of increased withdrawal and craving. This discomfort has the potential to make quitting smoking more difficult.

Indexed as

affective disorderscravingsnicotine dependencesmoking cessationtreatment and interventionwithdrawal symptoms

Identifiers

PMID27547173
PMCPMC4988686
OpenAlexW2086775293

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.