ArticleWorld journal of gastroenterology2016
Smaller tumor size is associated with poor survival in T4b colon cancer.
Article in World journal of gastroenterology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Prognostic Impact of Tumor Size in Patients with Stage T3N1 Colon Cancer.Journal of clinical medicine · 2025Article
- Oncologic outcomes of multivisceral resection for locally advanced colorectal cancer: a single-center retrospective cohort study.BMC surgery · 2025Article
- Association between tumor size and prognosis in patients with small bowel adenocarcinoma-a SEER-based study.Heliyon · 2024Article
- Article
- Impact of tumor size on overall survival and cancer-specific survival of early-onset colon and rectal cancer: a retrospective cohort study.International journal of colorectal disease · 2024Article
- The impact of tumor size on the prognosis and chemotherapy efficacy in stage I/II colon cancer patients.Journal of Cancer · 2024Article
- BICDL1 Predicts Poor Prognosis and is Correlated with Methylation and Immune Infiltration in Colorectal Cancer.Pharmacogenomics and personalized medicine · 2023Article
- Development and Validation of a Prediction Model for Predicting the Prognosis of Postoperative Patients with Hepatocellular Carcinoma.International journal of general medicine · 2022Article
- Predicting Distant Metastasis in Young-Onset Colorectal Cancer After Surgery: A Retrospective Study.Frontiers in oncology · 2022Article
- Pathological Features and Prognostication in Colorectal Cancer.Current oncology (Toronto, Ont.) · 2021Review
- Nomograms to predict cancer-specific mortality in colon adenocarcinoma with different types of villous architecture.International journal of colorectal disease · 2021Article
- Tumor size improves the accuracy of the prognostic prediction of T4a stage colon cancer.Scientific reports · 2021Article
- Evaluation of prognostic factors and clinicopathological patterns of recurrence after curative surgery for colorectal cancer.World journal of gastrointestinal surgery · 2021Article
- Predictive and Prognostic Effects of Primary Tumor Size on Colorectal Cancer Survival.Frontiers in oncology · 2021Article
- Favorable short-term oncologic outcomes following laparoscopic surgery for small T4 colon cancer: a multicenter comparative study.World journal of surgical oncology · 2020Article
- Modeling Tumor Evolutionary Dynamics to Predict Clinical Outcomes for Patients with Metastatic Colorectal Cancer: A Retrospective Analysis.Cancer research · 2020Article
- Development and Validation of a Prognostic Nomogram to Predict Cancer-Specific Survival in Adult Patients With Pineoblastoma.Frontiers in oncology · 2020Article
- Article
- Association between Race and Cancer-Related Mortality among Patients with Colorectal Cancer in the United States: A Retrospective Cohort Study.International journal of environmental research and public health · 2019Article
- Prognostic Value of the Tumor Size in Resectable Colorectal Cancer with Different Primary Locations: A Retrospective Study with the Propensity Score Matching.Journal of Cancer · 2019Article
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5 authors.
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Abstract
aimTo hypothesize that in patients with colon cancer showing heavy intestinal wall invasion without distant metastasis (T4bN0-2M0), small tumor size would correlate with more aggressive tumor behaviors and therefore poorer cancer-specific survival (CSS).
methodsWe analyzed T4bN0-2M0 colon cancer patients in the Surveillance, Epidemiology and End Results (SEER) database. A preliminary analysis of T4bN0-2M0 colon cancer patients at the Fudan University Shanghai Cancer Center is also presented.
resultsA total of 1734 T4bN0-2M0 colon cancer patients from the SEER database were included. Kaplan-Meier analysis revealed decreasing CSS with decreasing tumor size (P < 0.001). Subgroup analysis showed a significant association between poorer CSS with smaller tumor size in T4bN0 patients (P = 0.024), and a trend of association in T4bN1 (P = 0.182) and T4bN2 patients (P = 0.191). Multivariate analysis identified tumor size as an independent prognostic factor for CSS in T4bN0-2M0 patients (P = 0.024). Preliminary analysis of Fudan University Shanghai Cancer Center samples suggested the 5-year CSS was 50.0%, 72.9% and 77.1% in patients with tumors ≤ 4.0 cm, 4.0-7.0 cm and ≥ 7.0 cm.
conclusionSmaller tumor size is associated with poorer CSS in the T4bN0-2M0 subset of colon cancer, particularly in the T4bN0M0 subgroup.
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