ReviewTrends in neurosciences2016
Apolipoprotein E and Sex Bias in Cerebrovascular Aging of Men and Mice.
Review in Trends in neurosciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 29 citations in OpenAlex.
- Article
- Cerebral amyloid angiopathy: a narrative review.Frontiers in aging neuroscience · 2025Review
- Insufficient Mechanical Loading Downregulates Piezo1 in Chondrocytes and Impairs Fracture Healing Through ApoE-Induced Senescence.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Temporal Single Cell Analysis of Leukemia Microenvironment Identifies Taurine-Taurine Transporter Axis as a Key Regulator of Myeloid Leukemia.bioRxiv : the preprint server for biology · 2024Article
- Molecular basis of the association between transcription regulators nuclear respiratory factor 1 and inhibitor of DNA binding protein 3 and the development of microvascular lesions.Microvascular research · 2022Review
- Destabilizing heterochromatin by APOE mediates senescence.Nature aging · 2022Article
- Effects of age and sex on middle cerebral artery blood velocity and flow pulsatility index across the adult lifespan.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
- The APOE gene cluster responds to air pollution factors in mice with coordinated expression of genes that differs by age in humans.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2021Article
- Similar Genetic Architecture of Alzheimer's Disease and DifferentialFrontiers in aging neuroscience · 2021Article
- Sex-dependent calcium hyperactivity due to lysosomal-related dysfunction in astrocytes from APOE4 versus APOE3 gene targeted replacement mice.Molecular neurodegeneration · 2020Article
- Review
- Sex as a biological variable in the pathology and pharmacology of neurodegenerative and neurovascular diseases.British journal of pharmacology · 2019Review
- Modifiable Risk Factors Discriminate Memory Trajectories in Non-Demented Aging: Precision Factors and Targets for Promoting Healthier Brain Aging and Preventing Dementia.Journal of Alzheimer's disease : JAD · 2019Article
- Cerebral microhemorrhages due to traumatic brain injury and their effects on the aging human brain.Neurobiology of aging · 2018Review
- Sex Differences in Cognitive Decline in Subjects with High Likelihood of Mild Cognitive Impairment due to Alzheimer's disease.Scientific reports · 2018Article
- Corticotrophin releasing factor receptor 1 antagonists prevent chronic stress-induced behavioral changes and synapse loss in aged rats.Psychoneuroendocrinology · 2018Article
- Mediators of the Effect of Childhood Socioeconomic Status on Late Midlife Cognitive Abilities: A Four Decade Longitudinal Study.Innovation in aging · 2018Article
- Sex Differences in Autophagy Contribute to Female Vulnerability in Alzheimer's Disease.Frontiers in neuroscience · 2018Review
- EFAD transgenic mice as a humanJournal of lipid research · 2017Review
- Does selection for short sleep duration explain human vulnerability to Alzheimer's disease?Evolution, medicine, and public health · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Alzheimer disease (AD) research has mainly focused on neurodegenerative processes associated with the classic neuropathologic markers of senile plaques and neurofibrillary tangles. Additionally, cerebrovascular contributions to dementia are increasingly recognized, particularly from cerebral small vessel disease (SVD). Remarkably, in AD brains, the apolipoprotein E (ApoE) ɛ4 allele shows male excess for cerebral microbleeds (CMBs), a marker of SVD, which is opposite to the female excess of plaques and tangles. Mouse transgenic models add further complexities to sex-ApoE ɛ4 allele interactions, with female excess of both CMBs and brain amyloid. We conclude that brain aging and AD pathogenesis cannot be understood in humans without addressing major gaps in the extent of sex differences in cerebrovascular pathology.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.