ArticleLasers in surgery and medicine2017
In vivo endoscopic Doppler optical coherence tomography imaging of the colon.
Article in Lasers in surgery and medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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10 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- The clinical usefulness of optical coherence tomography during cancer interventions.Journal of cancer research and clinical oncology · 2018Pooled it
- A Precessing-Coin-like Rotary Actuator for Distal Endoscope Scanners: Proof-of-Concept Study.Micromachines · 2025Article
- High-resolution rectoscopy using MHz optical coherence tomography: a step towards real time 3D endoscopy.Scientific reports · 2024Article
- Computer-aided Veress needle guidance using endoscopic optical coherence tomography and convolutional neural networks.Journal of biophotonics · 2022Article
- Tumor models to assess immune response and tumor-microbiome interactions in colorectal cancer.Pharmacology & therapeutics · 2022Review
- Diagnosing colorectal abnormalities using scattering coefficient maps acquired from optical coherence tomography.Journal of biophotonics · 2021Article
- The Status of Advanced Imaging Techniques for Optical Biopsy of Colonic Polyps.Clinical and translational gastroenterology · 2020Review
- Real-time colorectal cancer diagnosis using PR-OCT with deep learning.Theranostics · 2020Article
- The Angular Spectrum of the Scattering Coefficient Map Reveals Subsurface Colorectal Cancer.Scientific reports · 2019Article
- Colposcopic imaging using visible-light optical coherence tomography.Journal of biomedical optics · 2017Article
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2 authors at 1 institution in 1 country.
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Abstract
BACKGROUND AND
objectiveColorectal cancer (CRC) remains the second deadliest cancer in the United States. Several screening methods exist; however, detection of small polyps remains a challenge. Optical coherence tomography (OCT) has been demonstrated to be capable of detecting lesions as small as 1 mm in the mouse colon, but detection is based on measuring a doubling of the mucosa thickness. The colon microvasculature may be an attractive biomarker of early tumor development because tumor vessels are characterized by irregular structure and dysfunction. Our goal was to develop an endoscopic method of detecting and segmenting colon vessels using Doppler OCT to enable future studies for improving early detection and development of novel chemopreventive agents.
methodWe conducted in vivo colon imaging in an azoxymethane (AOM)-treated mouse model of colorectal cancer using a miniature endoscope and a swept-source OCT system at 1,040 nm with a 16 kHz sweep rate. We applied the Kasai autocorrelation algorithm to laterally oversampled OCT B-scans to resolve vascular flow in the mucosa and submucosa. Vessels were segmented by applying a series of image processing steps: (i) intensity thresholding; (ii) two-dimensional matched filtering; and (iii) histogram segmentation.
resultsWe observed differences in the vessels sizes and spatial distribution in a mature adenoma compared to surrounding undiseased tissue and compared the results with histology. We also imaged flow in four young mice (two AOM-treated and two control) showing no significant differences, which is expected so early after carcinogen exposure. We also present flow images of adenoma in a living mouse and a euthanized mouse to demonstrate that no flow is detected after euthanasia.
conclusionWe present, to the best of our knowledge, the first Doppler OCT images of in vivo mouse colon collected with a fiber-based endoscope. We also describe a fast and robust image processing method for segmenting vessels in the colon. These results suggest that Doppler OCT is a promising imaging modality for vascular imaging in the colon that requires no exogenous contrast agents. Lasers Surg. Med. 49:249-257, 2017. © 2016 Wiley Periodicals, Inc.
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