Observational studyJournal of critical care2016
The association between hemoglobin concentration and neurologic outcome after cardiac arrest.
Observational study in Journal of critical care, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Brain Hypoxia Is Associated With Neuroglial Injury in Humans Post-Cardiac Arrest.Circulation research · 2021Trial
- Hemoglobin trends and transfusion practices after cardiac arrest: a cohort study.Journal of intensive care · 2026Article
- Article
- Association between early red blood cell transfusion after return of spontaneous circulation and clinical outcomes in cardiac arrest patients.Scientific reports · 2026Article
- Optimizing brain protection after cardiac arrest: advanced strategies and best practices.Interface focus · 2024Review
- Mechanisms and treatment of anemia related to cardiac arrest.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2024Review
- Critical Care Management of Patients After Cardiac Arrest: A Scientific Statement from the American Heart Association and Neurocritical Care Society.Neurocritical care · 2024Article
- Critical Care Management of Patients After Cardiac Arrest: A Scientific Statement From the American Heart Association and Neurocritical Care Society.Circulation · 2024Review
- Clinical targeting of the cerebral oxygen cascade to improve brain oxygenation in patients with hypoxic-ischaemic brain injury after cardiac arrest.Intensive care medicine · 2023Review
- Anemia before in-hospital cardiac arrest and survival from cardio-pulmonary resuscitation-a retrospective cohort study.Journal of anesthesia, analgesia and critical care · 2022Article
- Biocompatible and Biodegradable Polymer Optical Fiber for Biomedical Application: A Review.Biosensors · 2021Review
- Change of Hemoglobin Levels in the Early Post-cardiac Arrest Phase Is Associated With Outcome.Frontiers in medicine · 2021Article
- Glycated Hemoglobin is Associated with Glycemic Control and 6-Month Neurologic Outcome in Cardiac Arrest Survivors Undergoing Therapeutic Hypothermia.Neurocritical care · 2020Article
- Hemoglobin concentration is associated with neurologic outcome after cardiac arrest in patients treated with targeted temperature management.Clinical and experimental emergency medicine · 2018Article
- New Viewpoint in Exaggerated Increase of PtiOFrontiers in medicine · 2018Article
- Smartphone based optical spectrometer for diffusive reflectance spectroscopic measurement of hemoglobin.Scientific reports · 2017Article
- Clinical pathophysiology of hypoxic ischemic brain injury after cardiac arrest: a "two-hit" model.Critical care (London, England) · 2017Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
purposeThe purpose of the study is to determine the association between hemoglobin concentration (Hgb) and neurologic outcome in postarrest patients.
methodsWe conducted a retrospective cohort study using the Penn Alliance for Therapeutic Hypothermia (PATH) cardiac arrest registry. Inclusion criteria were resuscitated cardiac arrest (inhospital or out of hospital) and an Hgb value recorded within 24 hours of return of spontaneous circulation. The primary outcome was favorable neurologic status at hospital discharge. Survival to hospital discharge was a secondary outcome.
resultsThere were 598 eligible patients from 21 hospitals. Patients with favorable neurologic outcome had significantly higher median Hgb in the first 2 hours (12.7 vs 10.5 g/dL; P<.001) and 6 hours (12.6 vs 10.6 g/dL; P<.001) postarrest. Controlling for age, pulseless rhythm, etiology, location of arrest, receipt of targeted temperature management, hematologic or metastatic malignancy, or preexisting renal insufficiency, there was a significant relationship between Hgb and neurologic outcome within the first 6 hours after arrest (odds ratio, 1.23; 95% confidence interval, 1.09-1.38) and survival to hospital discharge (odds ratio, 1.20; 95% confidence interval, 1.08-1.34).
conclusionHigher Hgb after cardiac arrest is associated with favorable neurologic outcome, particularly within the first 6 hours. It is unclear if this effect is due to impaired oxygen delivery or if Hgb is a marker for more severe illness.
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