Evidence map›Paper›PMID 27546617›Full record

ReviewOncogene2017

Extracellular vesicles swarm the cancer microenvironment: from tumor-stroma communication to drug intervention.

F Wendler, R Favicchio, T Simon, C Alifrangis, J Stebbing, G Giamas

Abstract readReview
PubMed Publisher
In one paragraph

Review in Oncogene, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers.

0numbers the graph read from it
0cells of the map it votes in
89citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

89 citing papers in PubMed.

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29 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

F WendlerSchool of Life Sciences, Department of Biochemistry and Biomedicine, University of Sussex, Brighton, UK.
R FavicchioImperial College London, Department of Surgery and Cancer, Division of Cancer, London, UK.
T SimonSchool of Life Sciences, Department of Biochemistry and Biomedicine, University of Sussex, Brighton, UK.
C AlifrangisImperial College London, Department of Medical Oncology, NHS Trust, Hammersmith Hospital, London, UK.
J StebbingImperial College London, Department of Surgery and Cancer, Division of Cancer, London, UK.
G GiamasSchool of Life Sciences, Department of Biochemistry and Biomedicine, University of Sussex, Brighton, UK.

Funding

Cancer Research UK 14549Department of Health NIHR-RP-011-053Worldwide Cancer Research 10-0510
6 · The paper itself

Abstract

Intercellular communication sets the pace for transformed cells to survive and to thrive. Extracellular vesicles (EVs), such as exosomes, microvesicles and large oncosomes, are involved in this process shuttling reciprocal signals and other molecules between transformed and stromal cells, including fibroblasts, endothelial and immune cells. As a result, these cells are adapted or recruited to a constantly evolving cancer microenvironment. Moreover, EVs take part in the response to anticancer therapeutics not least by promoting drug resistance throughout the targeted tumor. Finally, circulating EVs can also transport important molecules to remote destinations in order to prime metastatic niches in an otherwise healthy tissue. Although the understanding of EV biology remains a major challenge in the field, their characteristics create new opportunities for advances in cancer diagnostics and therapeutics.

Indexed as

Tumor MicroenvironmentAnimalsCell CommunicationCell-Derived MicroparticlesExtracellular VesiclesHumansNeoplasmsStromal Cells

Identifiers

PMID27546617

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.