ReviewKidney international2016
An alternative hypothesis to the widely held view that renal excretion of sodium accounts for resistance to salt-induced hypertension.
Review in Kidney international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- α-Adrenergic receptor blockade attenuates pressor response during mental stress in young black adults.Physiological reports · 2021Trial
- Effect of high-salt diet on blood pressure and body fluid composition in patients with type 1 diabetes: randomized controlled intervention trial.BMJ open diabetes research & care · 2020Trial
- Quantitative dynamic contrast-enhanced magnetic resonance imaging for renal perfusion measurement in autosomal dominant polycystic kidney disease.Quantitative imaging in medicine and surgery · 2026Article
- Hemodynamic Mechanisms Initiating Salt-Sensitive Hypertension in Rat Model of Primary Aldosteronism.Physiological research · 2024Article
- The impact of excessive salt intake on human health.Nature reviews. Nephrology · 2022Review
- Mechanism-based strategies to prevent salt sensitivity and salt-induced hypertension.Clinical science (London, England : 1979) · 2022Article
- Sodium Accumulation and Blood Capillary Rarefaction in the Skin Predispose Spontaneously Hypertensive Rats to Salt Sensitive Hypertension.Biomedicines · 2022Article
- No evidence of racial disparities in blood pressure salt sensitivity when potassium intake exceeds levels recommended in the US dietary guidelines.American journal of physiology. Heart and circulatory physiology · 2021Review
- Tissue Sodium Content and Arterial Hypertension in Obese Adolescents.Journal of clinical medicine · 2019Article
- Sodium Intake and Hypertension.Nutrients · 2019Review
- Small Amounts of Inorganic Nitrate or Beetroot Provide Substantial Protection From Salt-Induced Increases in Blood Pressure.Hypertension (Dallas, Tex. : 1979) · 2019Article
- Testing Computer Models Predicting Human Responses to a High-Salt Diet.Hypertension (Dallas, Tex. : 1979) · 2018Article
- Functional foods for augmenting nitric oxide activity and reducing the risk for salt-induced hypertension and cardiovascular disease in Japan.Journal of cardiology · 2018Review
- 6-Gingerol Normalizes the Expression of Biomarkers Related to Hypertension via PPARPPAR research · 2018Article
- Reduced Renal Mass, Salt-Sensitive Hypertension Is Resistant to Renal Denervation.Frontiers in physiology · 2018Article
- Involvement of ENaC in the development of salt-sensitive hypertension.American journal of physiology. Renal physiology · 2017Review
- Eplerenone-Resistant Salt-Sensitive Hypertension in Nedd4-2 C2 KO Mice.International journal of molecular sciences · 2017Article
- Understanding the Two Faces of Low-Salt Intake.Current hypertension reports · 2017Review
- An Appraisal of Methods Recently Recommended for Testing Salt Sensitivity of Blood Pressure.Journal of the American Heart Association · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
It is widely held that in response to high salt diets, normal individuals are acutely and chronically resistant to salt-induced hypertension because they rapidly excrete salt and retain little of it so that their blood volume, and therefore blood pressure, does not increase. Conversely, it is also widely held that salt-sensitive individuals develop salt-induced hypertension because of an impaired renal capacity to excrete salt that causes greater salt retention and blood volume expansion than that which occurs in normal salt-resistant individuals. Here we review results of both acute and chronic salt-loading studies that have compared salt-induced changes in sodium retention and blood volume between normal subjects (salt-resistant normotensive control subjects) and salt-sensitive subjects. The results of properly controlled studies strongly support an alternative view: during acute or chronic increases in salt intake, normal salt-resistant subjects undergo substantial salt retention and do not excrete salt more rapidly, retain less sodium, or undergo lesser blood volume expansion than do salt-sensitive subjects. These observations: (i) directly conflict with the widely held view that renal excretion of sodium accounts for resistance to salt-induced hypertension, and (ii) have implications for contemporary understanding of how various genetic, immunologic, and other factors determine acute and chronic blood pressure responses to high salt diets.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.