ArticleCurrent biology : CB2016
The pdm3 Locus Is a Hotspot for Recurrent Evolution of Female-Limited Color Dimorphism in Drosophila.
Article in Current biology : CB, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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37 citing papers in PubMed, 72 citations in OpenAlex.
- The Genomic Landscape of Metallic Colour Variation in Ground Beetles.Molecular ecology · 2026Article
- Evolution of dominance in a Mendelian trait is linked to the evolution of environmental plasticity.Evolution; international journal of organic evolution · 2026Article
- Functional genetic elements of a butterfly mimicry supergene.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Ecology and sexual conflict drive the macroevolutionary dynamics of female-limited color polymorphisms in damselflies.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Similar Genetic Routes Are Independently Targeted for Mimetic Color Convergence in Bumble Bees.Molecular biology and evolution · 2025Article
- Evolution of dominance in a Mendelian trait is linked to the evolution of environmental plasticity.bioRxiv : the preprint server for biology · 2025Article
- Phylogenomic Analysis Reveals Evolutionary Relationships of Tropical Drosophilidae: FromEcology and evolution · 2025Article
- Lepidopteran scale cells derive from sensory organ precursors through a canonical lineage.Development (Cambridge, England) · 2025Article
- A genetic screen of transcription factors in the Drosophila melanogaster abdomen identifies novel pigmentation genes.G3 (Bethesda, Md.) · 2024Article
- Evidence for a single, ancient origin of a genus-wide alternative life history strategy.Science advances · 2023Article
- Drosophilids with darker cuticle have higher body temperature under light.Scientific reports · 2023Article
- Phylogenomic analyses of the genus Drosophila reveals genomic signals of climate adaptation.Molecular ecology resources · 2022Article
- Gene expression in male and female stickleback from populations with convergent and divergent throat coloration.Ecology and evolution · 2022Article
- Evolution of assortative mating following selective introgression of pigmentation genes between twoEcology and evolution · 2022Article
- Review
- DrosoPhyla: Resources for Drosophilid Phylogeny and Systematics.Genome biology and evolution · 2021Article
- Evolution of a neuromuscular sexual dimorphism in the Drosophila montium species group.Scientific reports · 2021Article
- The effect of theBiology letters · 2021Article
- A phylogeny for the Drosophila montium species group: A model clade for comparative analyses.Molecular phylogenetics and evolution · 2021Article
- Evolution of wing pigmentation in Drosophila: Diversity, physiological regulation, and cis-regulatory evolution.Development, growth & differentiation · 2020Review
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11 authors at 4 institutions in 3 countries.
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Abstract
Sex-limited polymorphisms are an intriguing form of sexual dimorphism that offer unique opportunities to reconstruct the evolutionary changes that decouple male and female traits encoded by a shared genome. We investigated the genetic basis of a Mendelian female-limited color dimorphism (FLCD) that segregates in natural populations of more than 20 species of the Drosophila montium subgroup. In these species, females have alternative abdominal color morphs, light and dark, whereas males have only one color morph in each species. A comprehensive molecular phylogeny of the montium subgroup supports multiple origins of FLCD. Despite this, we mapped FLCD to the same locus in four distantly related species-the transcription factor POU domain motif 3 (pdm3), which acts as a repressor of abdominal pigmentation in D. melanogaster. In D. serrata, FLCD maps to a structural variant in the first intron of pdm3; however, this variant is not found in the three other species-D. kikkawai, D. leontia, and D. burlai-and sequence analysis strongly suggests the pdm3 alleles responsible for FLCD originated independently at least three times. We propose that cis-regulatory changes in pdm3 form sexually dimorphic and monomorphic alleles that segregate within species and are preserved, at least in one species, by structural variation. Surprisingly, pdm3 has not been implicated in the evolution of sex-specific pigmentation outside the montium subgroup, suggesting that the genetic paths to sexual dimorphism may be constrained within a clade but variable across clades.
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