ArticleDevelopmental biology2016
FoxO regulates microtubule dynamics and polarity to promote dendrite branching in Drosophila sensory neurons.
Article in Developmental biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Optimizing CRISPR/Cas9 mutagenesis in Drosophila dendritic arborization neurons to avoid cytotoxicity.G3 (Bethesda, Md.) · 2026Article
- The conserved microtubule-associated protein Mini Spindles promotes dendrite branching and limits terminal branch elongation inmicroPublication biology · 2026Article
- γ-TuRCs and the augmin complex are required for the development of highly branched dendritic arbors in Drosophila.Journal of cell science · 2024Article
- The Zinc-BED Transcription Factor Bedwarfed Promotes Proportional Dendritic Growth and Branching through Transcriptional and Translational Regulation inInternational journal of molecular sciences · 2023Article
- The Zinc-BED transcription factor Bedwarfed promotes proportional dendritic growth and branching through transcriptional and translational regulation inbioRxiv : the preprint server for biology · 2023Article
- Article
- Armadillo regulates nociceptive sensitivity in the absence of injury.Molecular pain · 2022Article
- PP2A phosphatase regulates cell-type specific cytoskeletal organization to drive dendrite diversity.Frontiers in molecular neuroscience · 2022Article
- Relief Effects of Icariin on Inflammation-Induced Decrease of Tight Junctions in Intestinal Epithelial Cells.Frontiers in pharmacology · 2022Article
- Whole-brain efferent and afferent connectivity of mouse ventral tegmental area melanocortin-3 receptor neurons.The Journal of comparative neurology · 2021Article
- Role of Exendin-4 in Brain Insulin Resistance, Mitochondrial Function, and Neurite Outgrowth in Neurons under Palmitic Acid-Induced Oxidative Stress.Antioxidants (Basel, Switzerland) · 2021Article
- The ELAV/Hu protein Found in neurons regulates cytoskeletal and ECM adhesion inputs for space-filling dendrite growth.PLoS genetics · 2020Article
- FMRP-PKA Activity Negative Feedback Regulates RNA Binding-Dependent Fibrillation in Brain Learning and Memory Circuitry.Cell reports · 2020Article
- Article
- Low FoxO expression ineLife · 2020Article
- Conserved Tao Kinase Activity Regulates Dendritic Arborization, Cytoskeletal Dynamics, and Sensory Function inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- FOXO Regulates Neuromuscular Junction Homeostasis DuringFrontiers in aging neuroscience · 2020Article
- Genetic architecture of subcortical brain structures in 38,851 individuals.Nature genetics · 2019Article
- Age-Dependent Changes in Transcription Factor FOXO Targeting in FemaleFrontiers in genetics · 2019Article
- Coiled-coil structure-dependent interactions between polyQ proteins and Foxo lead to dendrite pathology and behavioral defects.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
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2 authors.
Funding
Abstract
The size and shape of dendrite arbors are defining features of neurons and critical determinants of neuronal function. The molecular mechanisms establishing arborization patterns during development are not well understood, though properly regulated microtubule (MT) dynamics and polarity are essential. We previously found that FoxO regulates axonal MTs, raising the question of whether it also regulates dendritic MTs and morphology. Here we demonstrate that FoxO promotes dendrite branching in all classes of Drosophila dendritic arborization (da) neurons. FoxO is required both for initiating growth of new branches and for maintaining existing branches. To elucidate FoxO function, we characterized MT organization in both foxO null and overexpressing neurons. We find that FoxO directs MT organization and dynamics in dendrites. Moreover, it is both necessary and sufficient for anterograde MT polymerization, which is known to promote dendrite branching. Lastly, FoxO promotes proper larval nociception, indicating a functional consequence of impaired da neuron morphology in foxO mutants. Together, our results indicate that FoxO regulates dendrite structure and function and suggest that FoxO-mediated pathways control MT dynamics and polarity.
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