ArticleScientific reports2016
Surface thermal oxidation on titanium implants to enhance osteogenic activity and in vivo osseointegration.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 186 citations in OpenAlex.
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- Effectiveness of Nano-hydroxyapatite-coated Implants against Peri-implantitis Bacteria.Journal of pharmacy & bioallied sciences · 2025Article
- WATER PLASMA TREATMENT METHOD: SIMULTANEOUS STERILIZATION AND SURFACE MODIFICATION OF TITANIUM-BASED IMPLANTS.Materials research (Sao Carlos, Sao Paulo, Brazil) · 2025Article
- Amorphous TiOBiomedical materials (Bristol, England) · 2024Article
- Titania (TiONanoscale · 2024Article
- Engineering a Hybrid Ti6Al4V-Based System for Responsive and Consistent Osteogenesis.ACS omega · 2024Article
- Effects of Electrical Parameters on Micro-Arc Oxidation Coatings on Pure Titanium.Micromachines · 2023Article
- Zinc (Zn) Doping by Hydrothermal and Alkaline Heat-Treatment Methods on Titania Nanotube Arrays for Enhanced Antibacterial Activity.Nanomaterials (Basel, Switzerland) · 2023Article
- Hydrogen Gas Sensing Properties of Mixed Copper-Titanium Oxide Thin Films.Sensors (Basel, Switzerland) · 2023Article
- An Experimental Anodized Titanium Surface for Transgingival Dental Implant Elements-Preliminary Report.Journal of functional biomaterials · 2023Article
- Antibacterial activity, cytocompatibility, and thermomechanical stability of TiMaterials today. Bio · 2022Article
- AMPK/mTOR Pathway Is Involved in Autophagy Induced by Magnesium-Incorporated TiOJournal of functional biomaterials · 2022Article
- Blood Coagulation on Titanium Dioxide Films with Various Crystal Structures on Titanium Implant Surfaces.Cells · 2022Article
- Article
- Manganese Oxide Nanozyme-Doped Diatom for Safe and Efficient Treatment of Peri-Implantitis.ACS applied materials & interfaces · 2022Article
- Effect of microtopography on osseointegration of implantable biomaterials and its modification strategies.Frontiers in bioengineering and biotechnology · 2022Review
- Titanium Nanobowl-Based Nest-Like Nanofiber Structure Prepared at Room Temperature and Pressure Promotes Osseointegration of Beagle Implants.Frontiers in bioengineering and biotechnology · 2022Article
- Single-Point Incremental Forming of Titanium and Titanium Alloy Sheets.Materials (Basel, Switzerland) · 2021Review
- Surface modification strategies to improve titanium hemocompatibility: a comprehensive review.Materials advances · 2021Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thermal oxidation, which serves as a low-cost, effective and relatively simple/facile method, was used to modify a micro-structured titanium surface in ambient atmosphere at 450 °C for different time periods to improve in vitro and in vivo bioactivity. The surface morphology, crystallinity of the surface layers, chemical composition and chemical states were evaluated by field-emission scanning electron microscopy (FESEM), X-ray diffraction (XRD), and X-ray photoelectron spectroscopy (XPS). Cell behaviours including cell adhesion, attachment, proliferation, and osteogenic differentiation were observed in vitro study. The ability of the titanium surface to promote osseointegration was evaluated in an in vivo animal model. Surface thermal oxidation on titanium implants maintained the microstructure and, thus, both slightly changed the nanoscale structure of titanium and enhanced the crystallinity of the titanium surface layer. Cells cultured on the three oxidized titanium surfaces grew well and exhibited better osteogenic activity than did the control samples. The in vivo bone-implant contact also showed enhanced osseointegration after several hours of oxidization. This heat-treated titanium enhanced the osteogenic differentiation activity of rBMMSCs and improved osseointegration in vivo, suggesting that surface thermal oxidation could potentially be used in clinical applications to improve bone-implant integration.
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