ArticleCell reports2016
mGluR-LTD at Excitatory and Inhibitory Synapses in the Lateral Habenula Tunes Neuronal Output.
Article in Cell reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 39 citations in OpenAlex.
- Basal forebrain-lateral habenula inputs and control of impulsive behavior.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- AKAP150-anchored PKA regulates synaptic transmission and plasticity, neuronal excitability and CRF neuromodulation in the mouse lateral habenula.Communications biology · 2024Article
- The mineralocorticoid receptor and extra-synaptic NMDA receptor in the lateral habenula involve in the vulnerability to early life stress in the maternal separation model.Neurobiology of stress · 2023Article
- Review
- Opposing retrograde and astrocyte-dependent endocannabinoid signaling mechanisms regulate lateral habenula synaptic transmission.Cell reports · 2023Article
- The intersection of astrocytes and the endocannabinoid system in the lateral habenula: on the fast-track to novel rapid-acting antidepressants.Molecular psychiatry · 2022Review
- Mild stress accumulation limits GABAergic synaptic plasticity in the lateral habenula.The European journal of neuroscience · 2022Article
- The Yin and Yang of GABAergic and Glutamatergic Synaptic Plasticity: Opposites in Balance by Crosstalking Mechanisms.Frontiers in synaptic neuroscience · 2022Review
- N-Methyl D-aspartate receptor subtype 2B/CaFrontiers in cellular neuroscience · 2022Article
- Lateral habenula cannabinoid CB1 receptor involvement in drug-associated impulsive behavior.Neuropharmacology · 2021Article
- Targeting Endocannabinoid Signaling in the Lateral Habenula as an Intervention to Prevent Mental Illnesses Following Early Life Stress: A Perspective.Frontiers in synaptic neuroscience · 2021Article
- NMDA receptor-dependent long-term depression in the lateral habenula: implications in physiology and depression.Scientific reports · 2020Article
- Circuits and functions of the lateral habenula in health and in disease.Nature reviews. Neuroscience · 2020Review
- MGluR5 activity is required for the induction of ethanol behavioral sensitization and associated changes in ERK MAP kinase phosphorylation in the nucleus accumbens shell and lateral habenula.Behavioural brain research · 2019Article
- Morphine withdrawal recruits lateral habenula cytokine signaling to reduce synaptic excitation and sociability.Nature neuroscience · 2019Article
- Group I mGluR-Mediated Activation of Martinotti Cells Inhibits Local Cortical Circuitry in Human Cortex.Frontiers in cellular neuroscience · 2019Article
- The Lateral Habenula Directs Coping Styles Under Conditions of Stress via Recruitment of the Endocannabinoid System.Biological psychiatry · 2018Article
- Metabotropic Glutamate Receptors in Alcohol Use Disorder: Physiology, Plasticity, and Promising Pharmacotherapies.ACS chemical neuroscience · 2018Article
- Article
- Review of the cytology and connections of the lateral habenula, an avatar of adaptive behaving.Pharmacology, biochemistry, and behavior · 2017Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Excitatory and inhibitory transmission onto lateral habenula (LHb) neurons is instrumental for the expression of positive and negative motivational states. However, insights into the molecular mechanisms modulating synaptic transmission and the repercussions for neuronal activity within the LHb remain elusive. Here, we report that, in mice, activation of group I metabotropic glutamate receptors triggers long-term depression at excitatory (eLTD) and inhibitory (iLTD) synapses in the LHb. mGluR-eLTD and iLTD rely on mGluR1 and PKC signaling. However, mGluR-dependent adaptations of excitatory and inhibitory synaptic transmission differ in their expression mechanisms. mGluR-eLTD occurs via an endocannabinoid receptor-dependent decrease in glutamate release. Conversely, mGluR-iLTD occurs postsynaptically through PKC-dependent reduction of β2-containing GABAA-R function. Finally, mGluR-dependent plasticity of excitation or inhibition decides the direction of neuronal firing, providing a synaptic mechanism to bidirectionally control LHb output. We propose mGluR-LTD as a cellular substrate that underlies LHb-dependent encoding of opposing motivational states.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.