ArticleNeuron2016
Cortical Feedback Regulates Feedforward Retinogeniculate Refinement.
Article in Neuron, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
- Nucleus-level thalamic organization anchors multimodal signatures of thalamocortical maturation.bioRxiv : the preprint server for biology · 2026Article
- Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome.Annals of clinical and translational neurology · 2026Article
- A single-cell transcriptomic atlas of sensory-dependent gene expression in developing mouse visual cortex.Development (Cambridge, England) · 2025Article
- Reciprocal interaction between cortical SST and PV interneurons in top-down regulation of retinothalamic refinement.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Experience influences the refinement of feature selectivity in the mouse primary visual thalamus.Neuron · 2025Article
- Experience-dependent plasticity of multiple receptive field properties in lateral geniculate binocular neurons during the critical period.Frontiers in cellular neuroscience · 2025Article
- Activity-Dependent Synapse Refinement: From Mechanisms to Molecules.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2024Review
- Pervasive alterations of intra-axonal volume and network organization in young children with a 16p11.2 deletion.Translational psychiatry · 2024Article
- Mapping the Retina onto the Brain.Cold Spring Harbor perspectives in biology · 2024Review
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- Cortical feedback modulates distinct critical period development in mouse visual thalamus.iScience · 2023Article
- Article
- Visual Deprivation Selectively Reduces Thalamic Reticular Nucleus-Mediated Inhibition of the Auditory Thalamus in Adults.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Cre driver mouse lines for thalamocortical circuit mapping.The Journal of comparative neurology · 2022Article
- Structural and Functional Plasticity in the Dorsolateral Geniculate Nucleus of Mice following Bilateral Enucleation.Neuroscience · 2022Article
- Epigenetic and Transcriptional Regulation of Spontaneous and Sensory Activity Dependent Programs During Neuronal Circuit Development.Frontiers in neural circuits · 2022Review
- Development of Functional Properties in the Early Visual System: New Appreciations of the Roles of Lateral Geniculate Nucleus.Current topics in behavioral neurosciences · 2022Review
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- Article
- Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
According to the prevailing view of neural development, sensory pathways develop sequentially in a feedforward manner, whereby each local microcircuit refines and stabilizes before directing the wiring of its downstream target. In the visual system, retinal circuits are thought to mature first and direct refinement in the thalamus, after which cortical circuits refine with experience-dependent plasticity. In contrast, we now show that feedback from cortex to thalamus critically regulates refinement of the retinogeniculate projection during a discrete window in development, beginning at postnatal day 20 in mice. Disrupting cortical activity during this window, pharmacologically or chemogenetically, increases the number of retinal ganglion cells innervating each thalamic relay neuron. These results suggest that primary sensory structures develop through the concurrent and interdependent remodeling of subcortical and cortical circuits in response to sensory experience, rather than through a simple feedforward process. Our findings also highlight an unexpected function for the corticothalamic projection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.