ArticleScientific reports2016
Molecular circadian rhythm shift due to bright light exposure before bedtime is related to subthreshold bipolarity.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 44 citations in OpenAlex.
- Bipolarity as an Independent Correlate of Clinical Profiles in Insomnia: A Factorial Analysis Across Multiple Clinical Domains.Brain and behavior · 2026Article
- Article
- Optimizing Chronotherapy in Psychiatric Care: The Impact of Circadian Rhythms on Medication Timing and Efficacy.Clocks & sleep · 2024Review
- Herbal and Natural Supplements for Improving Sleep: A Literature Review.Psychiatry investigation · 2024Article
- Stress, Dysregulation of Rhythms, and Bipolar Disorder: A Challenging Field of Research.Journal of clinical medicine · 2024Article
- Ensemble Approach to Combining Episode Prediction Models Using Sequential Circadian Rhythm Sensor Data from Mental Health Patients.Sensors (Basel, Switzerland) · 2023Article
- Seasonality of brain function: role in psychiatric disorders.Translational psychiatry · 2023Review
- Supersensitivity of Patients With Bipolar I Disorder to Light-Induced Phase Delay by Narrow Bandwidth Blue Light.Biological psychiatry global open science · 2022Article
- Combined cortisol and melatonin measurements with detailed parameter analysis can assess the circadian rhythms in bipolar disorder patients.Brain and behavior · 2021Article
- Similarities of Aspects of Biological Rhythms between Major Depression and Bipolar II Disorder Compared to Bipolar I Disorder: A Finding from the Early-Onset Mood Disorder Cohort.Psychiatry investigation · 2019Article
- Mood Prediction of Patients With Mood Disorders by Machine Learning Using Passive Digital Phenotypes Based on the Circadian Rhythm: Prospective Observational Cohort Study.Journal of medical Internet research · 2019Article
- Validation of the Korean Version of the Biological Rhythms Interview of Assessment in Neuropsychiatry.Psychiatry investigation · 2018Article
- Do We Use Artificial Light Appropriately?Psychiatry investigation · 2018Article
- Why Do Mania and Suicide Occur Most Often in the Spring?Psychiatry investigation · 2018Article
- Individuals with Restless Legs Syndrome Tend to have Severe Depressive Symptoms: Findings from a Community-Based Cohort Study.Psychiatry investigation · 2017Article
- Association between Excessive Use of Mobile Phone and Insomnia and Depression among Japanese Adolescents.International journal of environmental research and public health · 2017Article
- Advanced Circadian Phase in Mania and Delayed Circadian Phase in Mixed Mania and Depression Returned to Normal after Treatment of Bipolar Disorder.EBioMedicine · 2016Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study examined the link between circadian rhythm changes due to bright light exposure and subthreshold bipolarity. Molecular circadian rhythms, polysomnography, and actigraphy data were studied in 25 young, healthy male subjects, divided into high and low mood disorder questionnaire (MDQ) score groups. During the first 2 days of the study, the subjects were exposed to daily-living light (150 lux) for 4 hours before bedtime. Saliva and buccal cells were collected 5 times a day for 2 consecutive days. During the subsequent 5 days, the subjects were exposed to bright light (1,000 lux), and saliva and buccal cell samples were collected in the same way. Molecular circadian rhythms were analyzed using sine regression. Circadian rhythms of cortisol (F = 16.956, p < 0.001) and relative PER1/ARNTL gene expression (F = 122.1, p < 0.001) showed a delayed acrophase in both groups after bright light exposure. The high MDQ score group showed a significant delay in acrophase compared to the low MDQ score group only in salivary cortisol (F = 8.528, p = 0.008). The high MDQ score group showed hypersensitivity in cortisol rhythm shift after bright light exposure, suggesting characteristic molecular circadian rhythm changes in the high MDQ score group may be related to biological processes downstream from core circadian clock gene expression.
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