ArticleJournal of biophotonics2017
Autofluorescence hyperspectral imaging of radiofrequency ablation lesions in porcine cardiac tissue.
Article in Journal of biophotonics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Medical hyperspectral imaging: an updated review of technology advancements and biomedical applications.Journal of biomedical optics · 2026Pooled it
- Panoramic hyperspectral optical mapping of cardiac membrane potential and tissue type.Journal of biomedical optics · 2026Article
- Image-Based Monitoring of Thermal Ablation.Bioengineering (Basel, Switzerland) · 2025Review
- Robust, high-density lesion mapping in the left atrium with near-infrared spectroscopy.Journal of biomedical optics · 2024Article
- Niche preclinical and clinical applications of photoacoustic imaging with endogenous contrast.Photoacoustics · 2023Review
- Monitoring of irrigated lesion formation with single fiber based multispectral system using machine learning.Journal of biophotonics · 2022Article
- Cardiac endocardial left atrial substrate and lesion depth mapping using near-infrared spectroscopy.Biomedical optics express · 2022Article
- Prediction of In Vivo Laser-Induced Thermal Damage with Hyperspectral Imaging Using Deep Learning.Sensors (Basel, Switzerland) · 2021Article
- Hyperspectral Imagery for Assessing Laser-Induced Thermal State Change in Liver.Sensors (Basel, Switzerland) · 2021Article
- Autofluorescence properties of balloon polymers used in medical applications.Journal of biomedical optics · 2020Article
- A Percutaneous Catheter for In Vivo Hyperspectral Imaging of Cardiac Tissue: Challenges, Solutions and Future Directions.Cardiovascular engineering and technology · 2020Review
- Real-time photoacoustic assessment of radiofrequency ablation lesion formation in the left atrium.Photoacoustics · 2019Article
- Towards real-time multispectral endoscopic imaging for cardiac lesion quality assessment.Biomedical optics express · 2019Article
- Balloon catheter-based radiofrequency ablation monitoring in porcine esophagus using optical coherence tomography.Biomedical optics express · 2019Article
- Real-time optical spectroscopic monitoring of nonirrigated lesion progression within atrial and ventricular tissues.Journal of biophotonics · 2019Article
- Application of unsupervised learning to hyperspectral imaging of cardiac ablation lesions.Journal of medical imaging (Bellingham, Wash.) · 2018Article
- Optimization of wavelength selection for multispectral image acquisition: a case study of atrial ablation lesions.Biomedical optics express · 2018Article
- Hyperspectral imaging for label-free in vivo identification of myocardial scars and sites of radiofrequency ablation lesions.Heart rhythm · 2018Article
- Spectroscopic photoacoustic imaging of radiofrequency ablation in the left atrium.Biomedical optics express · 2018Article
- Anatomical and Optical Properties of Atrial Tissue: Search for a Suitable Animal Model.Cardiovascular engineering and technology · 2017Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Radiofrequency ablation (RFA) is a widely used treatment for atrial fibrillation, the most common cardiac arrhythmia. Here, we explore autofluorescence hyperspectral imaging (aHSI) as a method to visualize RFA lesions and interlesional gaps in the highly collagenous left atrium. RFA lesions made on the endocardial surface of freshly excised porcine left atrial tissue were illuminated by UV light (365 nm), and hyperspectral datacubes were acquired over the visible range (420-720 nm). Linear unmixing was used to delineate RFA lesions from surrounding tissue, and lesion diameters derived from unmixed component images were quantitatively compared to gross pathology. RFA caused two consistent changes in the autofluorescence emission profile: a decrease at wavelengths below 490 nm (ascribed to a loss of endogenous NADH) and an increase at wavelengths above 490 nm (ascribed to increased scattering). These spectral changes enabled high resolution, in situ delineation of RFA lesion boundaries without the need for additional staining or exogenous markers. Our results confirm the feasibility of using aHSI to visualize RFA lesions at clinically relevant locations. If integrated into a percutaneous visualization catheter, aHSI would enable widefield optical surgical guidance during RFA procedures and could improve patient outcome by reducing atrial fibrillation recurrence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.