ArticleScientific reports2016
Integrated application of transcriptomics and metabolomics yields insights into population-asynchronous ovary development in Coilia nasus.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Targeted Lipidomics and Transcriptomics Reveal Key Nutrients Regulating Ovarian Development inAnimals : an open access journal from MDPI · 2026Article
- Multi-tissue quantitative lipidomics reveals ovarian phospholipid remodeling across female reproductive states in anadromous Coilia nasus.Fish physiology and biochemistry · 2026Article
- Effects of dietary protein level on reproductive performance, transcriptomics and metabolomics of ovaries of female northern snakehead (Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2026Article
- Identifying sex-linked metabolomic biomarkers in fish gonads after bacterial infection.Metabolomics : Official journal of the Metabolomic Society · 2025Article
- Genome-Wide Identification, Expression and Response to Estrogen of Vitellogenin Gene Family in Sichuan Bream (International journal of molecular sciences · 2024Article
- A delayed and unsynchronized ovary development as revealed by transcriptome of brain and pituitary ofFrontiers in molecular biosciences · 2024Article
- Effects of Astaxanthin on Ovarian Development of Largemouth Bass (Aquaculture nutrition · 2024Article
- Transcriptomics Reveals the Mechanism ofNutrients · 2023Article
- Integrated Analysis of Transcriptomics and Metabolomics Unveil the Novel Insight of One-Year-Old Precocious Mechanism in the Chinese Mitten Crab,International journal of molecular sciences · 2023Article
- Gap-free genome assembly of anadromous Coilia nasus.Scientific data · 2023Article
- Integration of transcriptomic and metabolomic analysis of the mechanism of dietaryFrontiers in veterinary science · 2022Article
- Transcriptome analysis of five ovarian stages reveals gonad maturation in female Macrobrachium nipponense.BMC genomics · 2021Article
- Metabolome and Transcriptome Analysis of Liver and Oocytes ofFrontiers in genetics · 2021Article
- Variations and Potential Factors of Gut Prokaryotic Microbiome During Spawning Migration in Coilia nasus.Current microbiology · 2020Article
- Article
- Transcriptomic Analysis Revealed the Regulatory Mechanisms of Oocyte Maturation and Hydration in Orange-Spotted Grouper (Epinephelus coioides).Marine biotechnology (New York, N.Y.) · 2019Article
- Endocrine-disrupting chemicals in aquatic environment: what are the risks for fish gametes?Fish physiology and biochemistry · 2018Review
- Metabolomics Responses of Pearl Oysters (Frontiers in physiology · 2018Article
- Integrated application of transcriptomics and metabolomics provides insights into glycogen content regulation in the Pacific oyster Crassostrea gigas.BMC genomics · 2017Article
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5 authors.
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Abstract
Populations of Coilia nasus demonstrate asynchronous ovarian development, which severely restricts artificial breeding and large-scale cultivation. In this study, we used a combination of transcriptomic and metabolomic methods to identify the key signaling pathways and genes regulation affecting ovarian development. We identified 565 compounds and generated 47,049 unigenes from ovary tissue. Fifteen metabolites and 830 genes were significantly up-regulated, while 27 metabolites and 642 genes were significantly down-regulated from stage III to stage IV of ovary development. Meanwhile, 31 metabolites and 1,932 genes were significantly up-regulated, and four metabolites and 764 genes were down-regulated from stage IV to stage V. These differentially expressed genes and metabolites were enriched by MetScape. Forty-three and 50 signaling pathways had important functions from stage III-IV and from stage IV-V in the ovary, respectively. Among the above signaling pathways, 39 played important roles from ovarian stage III-V, including "squalene and cholesterol biosynthesis", "steroid hormone biosynthesis", and "arachidonate metabolism and prostaglandin formation" pathways which may thus have key roles in regulating asynchronous development. These results shed new light on our understanding of the mechanisms responsible for population-asynchronous development in fish.
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