ArticleBritish journal of clinical pharmacology2016
Road traffic crash risk associated with benzodiazepine and z-hypnotic use after implementation of a colour-graded pictogram: a responsibility study.
Article in British journal of clinical pharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Did the French pregnancy pictogram change antiseizure medication use during pregnancy?Epilepsia · 2026Article
- The FMB scale: a multifactorial metric to assess the driving hazard of medicines beyond the DRUID system.Therapeutic advances in drug safety · 2026Article
- Nonbenzodiazepine hypnotics and police-reported motor vehicle crash risk among older adults: a sequential target trial emulation.American journal of epidemiology · 2025Article
- Driving anxiety and anxiolytics while driving: Their impacts on behaviour and cognition behind the wheel.Heliyon · 2023Review
- Use of psychotropic medication and risk of road traffic crashes: a registry-based case-control study in Denmark, 1996-2018.Psychopharmacology · 2022Article
- Patterns of Benzodiazepine Use and Excess Risk of All-Cause Mortality in the Elderly: A Nationwide Cohort Study.Drug safety · 2021Article
- Article
- Trends in benzodiazepine anxiolytics and z-hypnotics use among French drivers involved in road traffic crashes from 2005 to 2015: a responsibility case-control study.Injury epidemiology · 2019Article
- Prescription medicine use by pedestrians and the risk of injurious road traffic crashes: A case-crossover study.PLoS medicine · 2017Article
- Cannabis, alcohol and fatal road accidents.PloS one · 2017Article
- Road traffic crash risk associated with benzodiazepine and z-hypnotic use after implementation of a colour-graded pictogram: a responsibility study.British journal of clinical pharmacology · 2016Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo assess potential change in medicine exposure and association with the risk of road traffic crash across a time period that started before the implementation of a grading system warning of the effect of medicine on driving performance.
methodsData from three French national databases were extracted and matched: the national health care insurance database, police reports and the national police database of injurious crashes. Drivers involved in such crashes in France, from July 2005 to December 2011 and identified by their national identifier, were included. Association with the risk of crash was estimated using a case-control analysis comparing benzodiazepine and z-hypnotic use among drivers responsible or not responsible for the crash.
resultsTotals of 69 353 responsible and 73 410 non-responsible drivers involved in an injurious crash were included. Exposure to benzodiazepine anxiolytics was associated with an increased risk of being responsible for a road traffic crash during the pre-intervention period (OR = 1.42 [1.24-1.62]). The association disappeared in the post-intervention period, but became significant again thereafter. The risk of being responsible for a crash increased in users of z-hypnotics across the study period.
conclusionsOur results question the efficacy of the measures implemented to promote awareness about the effects of medicines on driving abilities. Prevention policies relating to the general driving population, but also to healthcare professionals, should be reviewed.
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