ArticleEuropean journal of nuclear medicine and molecular imaging2017
Computed-tomography-guided anatomic standardization for quantitative assessment of dopamine transporter SPECT.
Article in European journal of nuclear medicine and molecular imaging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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14 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- The diagnostic performance of functional dopaminergic scintigraphic imaging in the diagnosis of dementia with Lewy bodies: an updated systematic review.European journal of nuclear medicine and molecular imaging · 2023Pooled it
- Performance of CT-guided spatial normalization for semi-quantification of dopamine transporter SPECT and detection of nigrostriatal degeneration.Annals of nuclear medicine · 2026Article
- Comparison of MRI-, CT- and PET-based anatomical standardization for Centiloid scale calculation in [Annals of nuclear medicine · 2026Article
- Comparison of the ability of different quantitative indices inJapanese journal of radiology · 2025Article
- Diagnostic Sensitivity and Symptomatic Relevance of Dopamine Transporter Imaging and Myocardial Sympathetic Scintigraphy in Patients with Dementia with Lewy Bodies.Journal of Alzheimer's disease : JAD · 2024Article
- Sex correction improves the accuracy of clinical dopamine transporter imaging.EJNMMI research · 2021Article
- A diagnostic strategy for Parkinsonian syndromes using quantitative indices of DAT SPECT and MIBG scintigraphy: an investigation using the classification and regression tree analysis.European journal of nuclear medicine and molecular imaging · 2021Article
- Creation of an anthropomorphic CT head phantom for verification of image segmentation.Medical physics · 2020Article
- Automatic classification of dopamine transporter SPECT: deep convolutional neural networks can be trained to be robust with respect to variable image characteristics.European journal of nuclear medicine and molecular imaging · 2019Article
- Two decades of SPECT/CT - the coming of age of a technology: An updated review of literature evidence.European journal of nuclear medicine and molecular imaging · 2019Review
- Quantitative Research ofFrontiers in neuroscience · 2019Article
- Semi-quantitative dopamine transporter standardized uptake value in comparison with conventional specific binding ratio in [123I] FP-CIT single-photon emission computed tomography (DaTscan).Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2018Article
- Japanese multicenter database of healthy controls for [European journal of nuclear medicine and molecular imaging · 2018Article
- InterpretingEuropean journal of hybrid imaging · 2018Article
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Authors and funding
9 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
purposeFor the quantitative assessment of dopamine transporter (DAT) using [
methodsWe retrospectively analyzed DaTscan images of 130 patients with parkinsonian syndromes (PS), including 80 PD and 50 non-PD patients. First we segmented gray matter from CT images using statistical parametric mapping 12 (SPM12). These gray-matter images were then anatomically standardized using the diffeomorphic anatomical registration using exponentiated Lie algebra (DARTEL) algorithm. Next, DaTscan images were warped with the same parameters used in the CT anatomic standardization. The target striatal VOIs for decreased DAT in PD were generated from the SPM12 group comparison of 20 DaTscan images from each group. We applied these VOIs to DaTscan images of the remaining patients in both groups and calculated the specific binding ratios (SBRs) using nonspecific counts in a reference area. In terms of the differential diagnosis of PD and non-PD groups using SBR, we compared the present method with two other methods, DaTQUANT and DaTView, which have already been released as software programs for the quantitative assessment of DaTscan images.
resultsThe SPM12 group comparison showed a significant DAT decrease in PD patients in the bilateral whole striatum. Of the three methods assessed, the present CT-guided method showed the greatest power for discriminating PD and non-PD groups, as it completely separated the two groups.
conclusionCT-guided anatomic standardization using the DARTEL algorithm is promising for the quantitative assessment of DaTscan images.
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