Evidence map›Paper›PMID 27544202›Full record

ArticleBrain imaging and behavior2017

Cognitive reserve and cortical thickness in preclinical Alzheimer's disease.

Corinne Pettigrew, Anja Soldan, Yuxin Zhu, Mei-Cheng Wang, Timothy Brown, Michael Miller, Marilyn Albert, BIOCARD Research Team

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Article in Brain imaging and behavior, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
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  6. Review
  7. Article
  8. Tracking early cognitive decline in preclinical AD with brain MRI similarity.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  9. Quantification of perforant path fibers for early detection of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Corinne PettigrewDepartment of Neurology, School of Medicine, Johns Hopkins University, Baltimore, MD, 21205, USA. cpettigrew@jhmi.edu.
Anja SoldanDepartment of Neurology, School of Medicine, Johns Hopkins University, Baltimore, MD, 21205, USA.
Yuxin ZhuDepartment of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, 21205, USA.
Mei-Cheng WangDepartment of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, 21205, USA.
Timothy BrownCenter for Imaging Science, Johns Hopkins University, Baltimore, MD, 21218, USA.
Michael MillerCenter for Imaging Science, Johns Hopkins University, Baltimore, MD, 21218, USA.
Marilyn AlbertDepartment of Neurology, School of Medicine, Johns Hopkins University, Baltimore, MD, 21205, USA.
BIOCARD Research Team

Funding

Project 2 MeasurementU19AG033655 · NIA · JOHNS HOPKINS UNIVERSITY · PI Abhay Moghekar · 2014 to 2026
$51.5M
'T V ASSESSMENT - MEMORY DISORDERED PATIENTS'P50AG005146 · NIA · JOHNS HOPKINS UNIVERSITY · PI HUGANIR, RICHARD L · 1985 to 2019
$37.6M
Biomarkers of Cognitive Decline among Normal Individuals: The BIOCARD cohortU01AG033655 · NIA · JOHNS HOPKINS UNIVERSITY · PI ALBERT, MARILYN S. · 2009 to 2013
$11.2M
Research Training in Age-Related Cognitive DisordersT32AG027668 · NIA · JOHNS HOPKINS UNIVERSITY · PI MARILYN S. ALBERT · 2007 to 2026
$6.3M
NIA NIH HHS P50 AG005146NIA NIH HHS T32 AG027668NIA NIH HHS U01 AG033655NIA NIH HHS U19 AG033655
6 · The paper itself

Abstract

This study examined whether cognitive reserve (CR) alters the relationship between magnetic resonance imaging (MRI) measures of cortical thickness and risk of progression from normal cognition to the onset of clinical symptoms associated with mild cognitive impairment (MCI). The analyses included 232 participants from the BIOCARD study. Participants were cognitively normal and largely middle aged (M age = 56.5) at their baseline MRI scan. After an average of 11.8 years of longitudinal follow-up, 48 have developed clinical symptoms of MCI or dementia (M time from baseline to clinical symptom onset = 7.0 years). Mean thickness was measured over eight 'AD vulnerable' cortical regions, and cognitive reserve was indexed by a composite score consisting of years of education, reading, and vocabulary measures. Using Cox regression models, CR and cortical thickness were each independently associated with risk of clinical symptom onset within 7 years of baseline, suggesting that the neuronal injury occurring proximal to symptom onset has a direct association with clinical outcomes, regardless of CR. In contrast, there was a significant interaction between CR and mean cortical thickness for risk of progression more than 7 years from baseline, suggesting that individuals with high CR are better able to compensate for cortical thinning that is beginning to occur at the very earliest phase of AD.

Indexed as

Cognitive ReserveAgingAlzheimer DiseaseAsymptomatic DiseasesBrain MappingCerebral CortexCognitive DysfunctionFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedOrgan SizeAlzheimer’s diseaseCognitive reserveCortical thicknessMagnetic resonance imagingPreclinical AD

Identifiers

PMID27544202
PMCPMC5743433

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.