ArticleCancer epidemiology2016
Socioeconomic status (SES) and childhood acute myeloid leukemia (AML) mortality risk: Analysis of SEER data.
Article in Cancer epidemiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Housing and Cancer Care and Outcomes: A Systematic Review.Journal of the National Cancer Institute · 2022Pooled it
- Social determinants of health and pediatric cancer survival: A systematic review.Pediatric blood & cancer · 2022Pooled it
- Impact of neighborhood archetypes on overall mortality among young patients with acute leukemia in California.Cancer · 2025Article
- Racial disparities in initiation of chemotherapy among breast cancer patients with discretionary treatment indication in the state of Georgia.Breast cancer research and treatment · 2024Article
- Determinants of Outcomes for Acute Myeloid Leukemia Patients Treated in a Community-Based Specialized Versus Non-Specialized Hospital Setting.Clinical hematology international · 2024Article
- How to use the Surveillance, Epidemiology, and End Results (SEER) data: research design and methodology.Military Medical Research · 2023Review
- [Socioeconomic status and cecal adenocarcinoma mortality risk: an American population-based analysis].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2023Article
- Widening Social Inequalities in Cancer Mortality of Children Under 5 Years in Korea.Journal of Korean medical science · 2023Article
- Time to Surgical Treatment and Facility Characteristics as Potential Drivers of Racial Disparities in Breast Cancer Mortality.Annals of surgical oncology · 2022Article
- Epidemiology and Etiology of Leukemia and Lymphoma.Cold Spring Harbor perspectives in medicine · 2020Review
- Associations between pretherapeutic body mass index, outcome, and cytogenetic abnormalities in pediatric acute myeloid leukemia.Cancer medicine · 2019Article
- Racial Disparities in Breast Cancer Outcomes in the Metropolitan Atlanta Area: New Insights and Approaches for Health Equity.JNCI cancer spectrum · 2019Article
- Cross-Cultural Medical Care Training and Education: a National Survey of Pediatric Hematology/Oncology Fellows-in-Training and Fellowship Program Directors.Journal of cancer education : the official journal of the American Association for Cancer Education · 2019Article
- Survival differences in childhood and young adult acute myeloid leukemia: A cross-national study using US and England data.Cancer epidemiology · 2018Article
- An overview of disparities in childhood cancer: Report on the Inaugural Symposium on Childhood Cancer Health Disparities, Houston, Texas, 2016.Pediatric hematology and oncology · 2018Article
- Survival After Childhood Cancer-Social Inequalities in High-Income Countries.Frontiers in oncology · 2018Article
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Authors and funding
3 authors.
Funding
Abstract
Socioeconomic status (SES) is a complex construct of multiple indicators, known to impact cancer outcomes, but has not been adequately examined among pediatric AML patients. This study aimed to identify the patterns of co-occurrence of multiple community-level SES indicators and to explore associations between various patterns of these indicators and pediatric AML mortality risk. A nationally representative US sample of 3651 pediatric AML patients, aged 0-19 years at diagnosis was drawn from 17 Surveillance, Epidemiology, and End Results (SEER) database registries created between 1973 and 2012. Factor analysis, cluster analysis, stratified univariable and multivariable Cox proportional hazards models were used. Four SES factors accounting for 87% of the variance in SES indicators were identified: F1) economic/educational disadvantage, less immigration; F2) immigration-related features (foreign-born, language-isolation, crowding), less mobility; F3) housing instability; and, F4) absence of moving. F1 and F3 showed elevated risk of mortality, adjusted hazards ratios (aHR) (95% CI): 1.07(1.02-1.12) and 1.05(1.00-1.10), respectively. Seven SES-defined cluster groups were identified. Cluster 1 (low economic/educational disadvantage, few immigration-related features, and residential-stability) showed the minimum risk of mortality. Compared to Cluster 1, Cluster 3 (high economic/educational disadvantage, high-mobility) and Cluster 6 (moderately-high economic/educational disadvantages, housing-instability and immigration-related features) exhibited substantially greater risk of mortality, aHR(95% CI)=1.19(1.0-1.4) and 1.23 (1.1-1.5), respectively. Factors of correlated SES-indicators and their pattern-based groups demonstrated differential risks in the pediatric AML mortality indicating the need of special public-health attention in areas with economic-educational disadvantages, housing-instability and immigration-related features.
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