Evidence map›Paper›PMID 27543838›Full record

ReviewCurrent opinion in microbiology2016

Protease regulation and capacity during Caulobacter growth.

Robert H Vass, Rilee D Zeinert, Peter Chien

Abstract readReview
In one paragraph

Review in Current opinion in microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. The Protein Quality Control Network inFrontiers in molecular biosciences · 2021
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. The Essential Role of ClpXP inFrontiers in molecular biosciences · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Robert H VassDepartment of Biochemistry and Molecular Biology, Molecular and Cellular Biology Graduate Program, University of Massachusetts Amherst, USA.
Rilee D ZeinertDepartment of Biochemistry and Molecular Biology, Molecular and Cellular Biology Graduate Program, University of Massachusetts Amherst, USA.
Peter ChienDepartment of Biochemistry and Molecular Biology, Molecular and Cellular Biology Graduate Program, University of Massachusetts Amherst, USA. Electronic address: pchien@biochem.umass.edu.

Funding

CHEMISTRY-BIOLOGY INTERFACE PREDOCTORAL TRAINING GRANTST32GM008515 · NIGMS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI THOMPSON, LYNMARIE K. · 1995 to 2020
$4.3M
Stress related proteases in Caulobacter crescentusR01GM111706 · NIGMS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI CHIEN, PETER · 2014 to 2018
$1.6M
NIGMS NIH HHS R01 GM111706NIGMS NIH HHS T32 GM008515
6 · The paper itself

Abstract

Cell growth requires the removal of proteins that are unwanted or toxic. In bacteria, AAA+ proteases like the Clp family and Lon selectively destroy proteins defined by intrinsic specificity or adaptors. Caulobacter crescentus is a gram-negative bacterium that undergoes an obligate developmental transition every cell division cycle. Here we highlight recent work that reveals how a hierarchy of adaptors targets the degradation of key proteins at specific times during this cell cycle, integrating protein destruction with other cues. We describe recent insight into how Caulobacter manages DNA replication and repair through Lon and Clp proteases. Because proteases must manage a broad substrate repertoire there must be methods to compensate for protease saturation and we discuss these scenarios.

Indexed as

Bacterial ProteinsCaulobacter crescentusCell CycleCell DivisionDNA, BacterialDNA ReplicationEndopeptidase ClpGene Expression Regulation, BacterialPeptide HydrolasesProtease LaBacterial ProteinsDNA, BacterialEndopeptidase ClpPeptide HydrolasesProtease La

Identifiers

PMID27543838
PMCPMC5164839

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.