ArticleInternational journal of cardiology2016
Normal age-related changes in left ventricular function: Role of afterload and subendocardial dysfunction.
Article in International journal of cardiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Cardiovascular effects of growth hormone (GH) treatment on GH-deficient adults: a meta-analysis update.Pituitary · 2020Pooled it
- A randomized controlled trial to establish effects of short-term rapamycin treatment in 24 middle-aged companion dogs.GeroScience · 2017Trial
- Early cardiotoxicity of radiotherapy in breast cancer patients after chemotherapy: the early warning sign.Journal of the Egyptian National Cancer Institute · 2026Observational
- Hemodynamic impact of acute liver injury on cardiac function: An in silico study via a closed-loop cardiovascular model.PLoS computational biology · 2026Article
- Prevalence and Long-Term Prognostic Significance of Advanced Diastolic Dysfunction Among Hospitalized Patients Referred for Echocardiography.Journal of clinical medicine · 2025Article
- Sex-specific differences in risk factors, comorbidities, diagnostic challenges, optimal management, and prognostic outcomes of heart failure with preserved ejection fraction: A comprehensive literature review.Heart failure reviews · 2024Review
- Hemodynamic Resuscitation Characteristics of Emergency Department Patients with Sepsis and Hypotension who are and are not Admitted to ICU; a Prospective Cross-sectional Study.Archives of academic emergency medicine · 2024Article
- The Impact of Left Ventricular Diastolic Dysfunction on Respiratory Adverse Events in Cardiac Surgery Patients-An Observational Prospective Single-Center Study.Journal of clinical medicine · 2023Article
- Fifth decennium after the arterial switch operation for transposition of the great arteries.International journal of cardiology. Congenital heart disease · 2023Article
- Age-Related Changes in Left Ventricular Vortex Formation and Flow Energetics.Journal of clinical medicine · 2021Article
- Real‑world challenge for clinicians treating advanced gastroesophageal adenocarcinoma (Review).International journal of oncology · 2021Review
- Cardiac tissue remodeling in healthy aging: the road to pathology.American journal of physiology. Cell physiology · 2020Review
- Beneficial Cardiac Structural and Functional Adaptations After Lumbosacral Spinal Cord Epidural Stimulation and Task-Specific Interventions: A Pilot Study.Frontiers in neuroscience · 2020Article
- Article
- Age related structural and functional changes in left ventricular performance in healthy subjects: a 2D echocardiographic study.The international journal of cardiovascular imaging · 2019Article
- Characterization of Myocardial Microstructure and Function in an Experimental Model of Isolated Subendocardial Damage.Hypertension (Dallas, Tex. : 1979) · 2019Article
- Mechanisms, diagnosis, and treatment of heart failure with preserved ejection fraction and diastolic dysfunction.Expert review of cardiovascular therapy · 2018Review
- Left ventricular functional, structural and energetic effects of normal aging: Comparison with hypertension.PloS one · 2017Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundIn normal ageing, both vascular and ventricular properties change, and how these affect left ventricular function is not clear.
methods96 subjects (ages 20-79) without cardiovascular disease underwent cardiac magnetic resonance (MR) imaging for measurement of global function, diastolic function (E/A ratio), MR tagging for measurement of torsion to shortening ratio (TSR, ratio of epicardial torsion to endocardial circumferential shortening, with increase in TSR suggesting subendocardial dysfunction relative to the subepicardium), and phase contrast MR imaging measurement of central aortic pulse wave velocity (PWV). The Vicorder device was used to measure carotid to femoral PWV.
resultsUnivariate correlations established that the 4 principal age-related changes in the left ventricular function were: 1) diastolic function: E/A ratio (r: -0.61, p<0.00001); 2) global systolic function: cardiac output (r: -0.49, p<0.00001), 3) structure: end-diastolic volume index (r: -0.39, p<0.0001), and 4) systolic strains: TSR (r: 0.49, p<0.0001). Multiple linear regression analysis showed that age was the dominant factor in predicting changes in cardiac output and E/A ratio (both p<0.01). Increased TSR was significantly related to reduced cardiac output and end-diastolic volume index (p<0.05 and p<0.01 respectively). Measures of vascular stiffness were not significantly related to any of these variables, but increased effective arterial elastance (afterload) was significantly related to reduced E/A ratio (p<0.05).
conclusionsIn this group of normal ageing subjects, afterload but not vascular stiffness is significantly related to diastolic dysfunction. Increased TSR, suggesting relative subendocardial dysfunction, has a significant role in reductions of cardiac output and end-diastolic volume index.
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