ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2016
Association between Vitamin D Deficiency and Antinuclear Antibodies in Middle-Aged and Older U.S. Adults.
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Observational
- Sex-specific relationship between serum 25-hydroxyvitamin D concentrations and antinuclear antibodies in U.S. adults, NHANES 2001-2004.BMC immunology · 2024Article
- Sunscreen use associated with elevated prevalence of anti-nuclear antibodies in U.S. adults.Journal of autoimmunity · 2024Article
- Vitamin D levels in non-pregnant women with a history of recurrent pregnancy loss with and without autoantibodies.Caspian journal of internal medicine · 2024Article
- Bullous pemphigoid anti-BP180-NC16A autoantibody reactivity in healthy individuals is associated with marked hypovitaminosis D and Th2-like cytokine predominance.Archives of dermatological research · 2023Article
- The clinical significance of anti-DFS70 autoantibodies and its correlation with Vitamin D levels.Northern clinics of Istanbul · 2022Article
- Hygiene Hypothesis Indicators and Prevalence of Antinuclear Antibodies in US Adolescents.Frontiers in immunology · 2022Article
- Benzophenone-3 and antinuclear antibodies in U.S. adolescents and adults ages 12-39 years.Frontiers in immunology · 2022Article
- Antinuclear antibodies and mortality in the National Health and Nutrition Examination Survey (1999-2004).PloS one · 2017Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundVitamin D deficiency is associated with cancer and autoimmune diseases, but little is known about the association between vitamin D and antinuclear antibodies (ANA), a biomarker of immune dysfunction in healthy populations. The objective of this study was to determine whether vitamin D deficiency is associated with ANA in middle-aged and older U.S. adults.
methodsA cross-sectional analysis using the National Health and Nutrition Examination Survey (NHANES) 2001-2004 was conducted. Data were available for 1,012 adults aged 50 years and older. Serum 25-hydroxyvitamin D levels were measured by radioimmunoassay. ANA was measured in a 1:80 dilution of sera by immunofluorescence using HEp-2 cells (seropositive = 3 or 4+).
resultsGreater vitamin D deficiency was associated with higher ANA prevalence in the unadjusted (P
conclusionsAmong U.S. residents ages 50 and older, vitamin D deficiency was associated with higher prevalence of ANA. Vitamin D sufficiency may be important for preventing immune dysfunction in older populations. IMPACT: Our findings support the growing evidence that vitamin D is an important immune modulator. Vitamin D deficiency in older adults may increase vulnerability to cancer by contributing to immune dysfunction. Cancer Epidemiol Biomarkers Prev; 25(12); 1559-63. ©2016 AACR.
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