Evidence map›Paper›PMID 27543500›Full record

Trial reportOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2017

Acute effects of calcium supplements on blood pressure: randomised, crossover trial in postmenopausal women.

E O Billington, S M Bristow, G D Gamble, J A de Kwant, A Stewart, B V Mihov, A M Horne, I R Reid

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03783273 (The Influence of Food Matrix Delivery System on the Bioavailability of Vitamin D3), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03783273 nacompletednot on this mapstarted 2019, after this paper: background citation

The Influence of Food Matrix Delivery System on the Bioavailability of Vitamin D3

TypeinterventionalSponsorUniversity of AarhusRan2019 to 2020Enrolled30ConditionsVitamin D DeficiencyArmsVitamin D3, Whey protein-complex, Water, Milk, Juice
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. The effect of calcium and vitamin D supplements on blood pressure in postmenopausal women: myth or reality?Hypertension research : official journal of the Japanese Society of Hypertension · 2022
    Trial
  2. Trial
  3. Trial
  4. Review
  5. Article
  6. Calcium Supplementation- Efficacy and Safety.Current osteoporosis reports · 2025
    Review
  7. Article
  8. Calcium and Cardiovascular Disease.Endocrinology and metabolism (Seoul, Korea) · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

E O BillingtonDepartment of Medicine, The University of Auckland, Private Bag 92019, Auckland Mail Centre 1142, Auckland, New Zealand.
S M BristowDepartment of Medicine, The University of Auckland, Private Bag 92019, Auckland Mail Centre 1142, Auckland, New Zealand. s.bristow@auckland.ac.nz.
G D GambleDepartment of Medicine, The University of Auckland, Private Bag 92019, Auckland Mail Centre 1142, Auckland, New Zealand.
J A de KwantDepartment of Medicine, The University of Auckland, Private Bag 92019, Auckland Mail Centre 1142, Auckland, New Zealand.
A StewartDepartment of Medicine, The University of Auckland, Private Bag 92019, Auckland Mail Centre 1142, Auckland, New Zealand.
B V MihovDepartment of Medicine, The University of Auckland, Private Bag 92019, Auckland Mail Centre 1142, Auckland, New Zealand.
A M HorneDepartment of Medicine, The University of Auckland, Private Bag 92019, Auckland Mail Centre 1142, Auckland, New Zealand.
I R ReidDepartment of Medicine, The University of Auckland, Private Bag 92019, Auckland Mail Centre 1142, Auckland, New Zealand.
University of Auckland · NZUniversity of Calgary · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Calcium supplements appear to increase cardiovascular risk, but the mechanism is unknown. We investigated the acute effects of calcium supplements on blood pressure in postmenopausal women. The reduction in systolic blood pressure was smaller after calcium compared with the placebo in the hours following dosing.

introductionCalcium supplements appear to be associated with increased cardiovascular risk; however, the mechanism of this is uncertain. We previously reported that blood pressure declined over a day in older women, and that this reduction was smaller following a calcium supplement. To confirm this finding, we investigated the acute effects of calcium supplements on blood pressure.

methodsThis was a randomised controlled crossover trial in 40 healthy postmenopausal women (mean age 71 years and BMI 27.2 kg/m

resultsIonised and total calcium concentrations increased after calcium (p < 0.0001 versus placebo). Systolic blood pressure decreased after both calcium and placebo, but significantly less so after calcium (p = 0.02). The reduction in systolic blood pressure from baseline was smaller after calcium compared with placebo by 6 mmHg at 4 h (p = 0.036) and by 9 mmHg at 6 h (p = 0.002). The reduction in diastolic blood pressure was similar after calcium and placebo.

conclusionsThese findings are consistent with those of our previous trial and indicate that the use of calcium supplements in postmenopausal women attenuates the post-breakfast reduction in systolic blood pressure by around 6-9 mmHg. Whether these changes in blood pressure influence cardiovascular risk requires further study.

Indexed as

Dietary SupplementsAgedBlood PressureBone Density Conservation AgentsCalcium CitrateCross-Over StudiesDouble-Blind MethodFemaleHumansOsteoporosis, PostmenopausalPostmenopauseBone Density Conservation AgentsCalcium CitrateBlood pressureCalcium supplementsOsteoporosisRandomised trial

Identifiers

PMID27543500
OpenAlexW2511766130

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.