Evidence map›Paper›PMID 27543472›Full record

Trial reportIndian heart journal

A randomized study of coconut oil versus sunflower oil on cardiovascular risk factors in patients with stable coronary heart disease.

Maniyal Vijayakumar, D M Vasudevan, K R Sundaram, Sajitha Krishnan, Kannan Vaidyanathan, Sandya Nandakumar, Rajiv Chandrasekhar, Navin Mathew

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Indian heart journal. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06995586 (The Synergistic Action of Vitamins and Dietary Supplements in Patients With Coronary Artery Bypass Grafting for Improving the Quality of Healthcare Delivery.), which is not on this map. Cited by 32 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 7 pooled it
6.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06995586 nanot yet recruitingnot on this map

The Synergistic Action of Vitamins and Dietary Supplements in Patients With Coronary Artery Bypass Grafting for Improving the Quality of Healthcare Delivery.

TypeinterventionalSponsorNicosia General HospitalRan2026 to 2028Enrolled108ConditionsCardio-pulmonary Bypass, Cardiovascular Diseases, Omega-3 Polyunsaturated Fatty Acids, Omega-3 SupplementationArmsVitamin C, Omega 3 PUFA (EPO/DHA), Lignin, Lactulose
3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 7 syntheses or guidelines pooled it, 88 citations in OpenAlex.

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  19. Coconut Oil and Cardiovascular Disease Risk.Current atherosclerosis reports · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Maniyal VijayakumarProfessor of Cardiology, Amrita Institute of Medical Sciences and Research Centre (Amrita Vishwa Vidyapeetham University), AIMS Ponekkara P.O., Kochi, Kerala, India. Electronic address: drmvijay@aims.amrita.edu.
D M VasudevanProfessor Biochemistry, Amrita Institute of Medical Sciences and Research Centre (Amrita Vishwa Vidyapeetham University), AIMS Ponekkara P.O., Kochi, Kerala, India.
K R SundaramProfessor Biostatistics, Amrita Institute of Medical Sciences and Research Centre (Amrita Vishwa Vidyapeetham University), AIMS Ponekkara P.O., Kochi, Kerala, India.
Sajitha KrishnanProfessor Biochemistry, Amrita Institute of Medical Sciences and Research Centre (Amrita Vishwa Vidyapeetham University), AIMS Ponekkara P.O., Kochi, Kerala, India.
Kannan VaidyanathanAssociate Professor, Department of Biochemistry, Amrita Institute of Medical Sciences and Research Center (Amrita Vishwa Vidaypeetham University), India.
Sandya NandakumarResearch Fellow, Amrita Institute of Medical Sciences and Research Centre (Amrita Vishwa Vidyapeetham University), AIMS Ponekkara P.O., Kochi, Kerala, India.
Rajiv ChandrasekharProfessor of Cardiology, Amrita Institute of Medical Sciences and Research Centre (Amrita Vishwa Vidyapeetham University), AIMS Ponekkara P.O., Kochi, Kerala, India.
Navin MathewProfessor of Cardiology, Amrita Institute of Medical Sciences and Research Centre (Amrita Vishwa Vidyapeetham University), AIMS Ponekkara P.O., Kochi, Kerala, India.
Amrita Institute of Medical Sciences and Research Centre · INAmrita Vishwa Vidyapeetham · INInstitute of Medical Sciences · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and rationaleCoronary artery disease (CAD) and its pathological atherosclerotic process are closely related to lipids. Lipids levels are in turn influenced by dietary oils and fats. Saturated fatty acids increase the risk for atherosclerosis by increasing the cholesterol level. This study was conducted to investigate the impact of cooking oil media (coconut oil and sunflower oil) on lipid profile, antioxidant mechanism, and endothelial function in patients with established CAD. DESIGN AND

methodsIn a single center randomized study in India, patients with stable CAD on standard medical care were assigned to receive coconut oil (Group I) or sunflower oil (Group II) as cooking media for 2 years. Anthropometric measurements, serum, lipids, Lipoprotein a, apo B/A-1 ratio, antioxidants, flow-mediated vasodilation, and cardiovascular events were assessed at 3 months, 6 months, 1 year, and 2 years.

resultsHundred patients in each arm completed 2 years with 98% follow-up. There was no statistically significant difference in the anthropometric, biochemical, vascular function, and in cardiovascular events after 2 years.

conclusionCoconut oil even though rich in saturated fatty acids in comparison to sunflower oil when used as cooking oil media over a period of 2 years did not change the lipid-related cardiovascular risk factors and events in those receiving standard medical care.

Indexed as

Coconut OilCoronary DiseaseDietary FatsFemaleFollow-Up StudiesHumansIncidenceIndiaLipidsMaleMiddle AgedPilot ProjectsPlant OilsSingle-Blind MethodSunflower OilTime FactorsCoconut OilDietary FatsLipidsPlant OilsSunflower OilAtherosclerosisCholesterolCoconut oilCooking mediumSunflower oil

Identifiers

PMID27543472
PMCPMC4990731
OpenAlexW2273941262

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.