Evidence map›Paper›PMID 27543294›Full record

ArticleG3 (Bethesda, Md.)2016

Sporadic Gene Loss After Duplication Is Associated with Functional Divergence of Sirtuin Deacetylases Among Candida Yeast Species.

Christopher B Rupert, Justin M H Heltzel, Derek J Taylor, Laura N Rusche

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in G3 (Bethesda, Md.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.2field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
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  4. Effects of Hst3p inhibition inFrontiers in cellular and infection microbiology · 2022
    Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Christopher B RupertDepartment of Biological Sciences, State University of New York at Buffalo, New York 14260.
Justin M H HeltzelDepartment of Biological Sciences, State University of New York at Buffalo, New York 14260.
Derek J TaylorDepartment of Biological Sciences, State University of New York at Buffalo, New York 14260.
Laura N RuscheDepartment of Biological Sciences, State University of New York at Buffalo, New York 14260 lrusche@buffalo.edu.
University at Buffalo, State University of New York · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gene duplication promotes the diversification of protein functions in several ways. Ancestral functions can be partitioned between the paralogs, or a new function can arise in one paralog. These processes are generally viewed as unidirectional. However, paralogous proteins often retain related functions and can substitute for one another. Moreover, in the event of gene loss, the remaining paralog might regain ancestral functions that had been shed. To explore this possibility, we focused on the sirtuin deacetylase SIR2 and its homolog HST1 in the CTG clade of yeasts. HST1 has been consistently retained throughout the clade, whereas SIR2 is only present in a subset of species. These NAD

Indexed as

Gene DeletionGene DuplicationAcetylationCandidaFungal ProteinsGenetic LociGenotypeGroup III Histone DeacetylasesHistonesPhylogenySirtuin 2TelomereFungal ProteinsGroup III Histone DeacetylasesHistonesSirtuin 2CTG cladeHst1Sir2specifically retained ancestral gene

Identifiers

PMID27543294
PMCPMC5068949
OpenAlexW2512178530

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.