Evidence map›Paper›PMID 27543292›Full record

ArticleG3 (Bethesda, Md.)2016

RNAi-Based Suppressor Screens Reveal Genetic Interactions Between the CRL2LRR-1 E3-Ligase and the DNA Replication Machinery in Caenorhabditis elegans.

Batool Ossareh-Nazari, Anthi Katsiarimpa, Jorge Merlet, Lionel Pintard

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in G3 (Bethesda, Md.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. CUL-2Nature cell biology · 2017
    Article
  6. Terminating the replication helicase.Nature cell biology · 2017
    Article
  7. CRL2Genes & development · 2017
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Batool Ossareh-NazariJacques Monod Institute, Paris-Diderot University, Centre National de la Recherche Scientifique, 75013 Paris, France.
Anthi KatsiarimpaJacques Monod Institute, Paris-Diderot University, Centre National de la Recherche Scientifique, 75013 Paris, France.
Jorge MerletJacques Monod Institute, Paris-Diderot University, Centre National de la Recherche Scientifique, 75013 Paris, France.
Lionel PintardJacques Monod Institute, Paris-Diderot University, Centre National de la Recherche Scientifique, 75013 Paris, France lionel.pintard@ijm.fr.ORCID 0000-0003-0286-4630
Institut Jacques Monod · FRUniversité Paris Cité · FR

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
NIH HHS P40 OD010440
6 · The paper itself

Abstract

Cullin-RING E3-Ligases (CRLs), the largest family of E3 ubiquitin-Ligases, regulate diverse cellular processes by promoting ubiquitination of target proteins. The evolutionarily conserved Leucine Rich Repeat protein 1 (LRR-1) is a substrate-recognition subunit of a CRL2

Indexed as

DNA ReplicationEpistasis, GeneticGene Expression RegulationRNA InterferenceAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsGenetic TestingMultiprotein ComplexesMutationProtein SubunitsReceptors, CytokineUbiquitin-Protein LigasesCaenorhabditis elegans ProteinsMultiprotein ComplexesProtein SubunitsReceptors, CytokineUbiquitin-Protein LigasesC. elegansCullin-RING E3-LigasesDNA replicationMutant Screen Report

Identifiers

PMID27543292
PMCPMC5068962
OpenAlexW2517728949

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.