SynthesisEBioMedicine2016
Genetic Risk Can Be Decreased: Quitting Smoking Decreases and Delays Lung Cancer for Smokers With High and Low CHRNA5 Risk Genotypes - A Meta-Analysis.
Open access · goldAbstract readMeta-Analysis
In one paragraph
Synthesis in EBioMedicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
4.3field-weighted citation impact, top 6% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Lung Cancer Screening, Version 3.2018, NCCN Clinical Practice Guidelines in Oncology.Journal of the National Comprehensive Cancer Network : JNCCN · 2018Guideline
- Proof of Concept of a Personalized Genetic Risk Tool to Promote Smoking Cessation: High Acceptability and Reduced Cigarette Smoking.Cancer prevention research (Philadelphia, Pa.) · 2021Trial
- Oral Vitamin C (500 mg/d) to Pregnant Smokers Improves Infant Airway Function at 3 Months (VCSIP). A Randomized Trial.American journal of respiratory and critical care medicine · 2019Trial
- Longevity-associatedTranslational lung cancer research · 2026Article
- Impact of smoking reduction on lung cancer risk in patients with COPD who smoked fewer than 30 pack-years: a nationwide population-based cohort study.Respiratory research · 2024Article
- Identifying and assessing a prognostic model based on disulfidptosis-related genes: implications for immune microenvironment and tumor biology in lung adenocarcinoma.Frontiers in immunology · 2024Article
- Genomic medicine to reduce tobacco and related disorders: Translation to precision prevention and treatment.Addiction neuroscience · 2023Article
- The rs16969968 Tobacco Smoking-Related Single-Nucleotide Variant Is Associated with Clinical Markers in Patients with Severe COVID-19.International journal of molecular sciences · 2023Article
- Neuroepigenetic alterations in the prefrontal cortex of type 2 diabetic mice through DNA hypermethylation.Molecular biology reports · 2022Article
- CHRNA5 Contributes to Hepatocellular Carcinoma Progression by Regulating YAP Activity.Pharmaceutics · 2022Article
- Gene signature to predict prognostic survival of hepatocellular carcinoma.Open medicine (Warsaw, Poland) · 2022Article
- Targeting lung cancer screening to individuals at greatest risk: the role of genetic factors.Journal of medical genetics · 2021Article
- Participatory Design of a Personalized Genetic Risk Tool to Promote Behavioral Health.Cancer prevention research (Philadelphia, Pa.) · 2020Article
- Nicotinic-nAChR signaling mediates drug resistance in lung cancer.Journal of Cancer · 2020Review
- Influence of Social Connections on Smoking Behavior across the Life Course.Advances in life course research · 2019Article
- Smoking index, lifestyle factors, and genomic instability assessed by single-cell gel electrophoresis: a cross-sectional study in subjects from Yucatan, Mexico.Clinical epigenetics · 2019Article
- Acetylcholine signaling system in progression of lung cancers.Pharmacology & therapeutics · 2019Review
- Finding paths with the greatest chance of success: enabling and focusing lung cancer screening and cessation in resource-constrained areas.Translational lung cancer research · 2018Article
- On the Nature of Evidence and 'Proving' Causality: Smoking and Lung Cancer vs. Sun Exposure, Vitamin D and Multiple Sclerosis.International journal of environmental research and public health · 2018Article
- Molecular mechanisms of the preventable causes of cancer in the United States.Genes & development · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
50 authors at 20 institutions in 8 countries.
Li-Shiun ChenDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA; Siteman Cancer Center, Washington University, St. Louis, MO, USA. Electronic address: chenli@psychiatry.wustl.edu.
Timothy BakerTobacco Research and Intervention, University of Wisconsin, School of Medicine, Madison, WI, USA.
Rayjean J HungLunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Canada.
Amy HortonDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Robert CulverhouseDepartment of Medicine, Washington University School of Medicine, St. Louis, MO.
Sarah HartzDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Nancy SacconeDepartment of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
Iona ChengCancer Prevention Institute of California, Fremont, CA, USA.
Bo DengDivision of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN, USA.
Younghun HanDepartment of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
Helen M HansenDepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.
Janet HorsmanDepartment of Oncology, University of Sheffield, Sheffield, UK.
Claire KimDepartment of Epidemiology, UCLA Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA, USA.
Albert RosenbergerDepartment of Genetic Epidemiology, University of Goettingen Medical School, Goettingen, Germany.
Katja K AbenNetherlands Comprehensive Cancer Organization, Utrecht, The Netherlands & Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands.
Angeline S AndrewNorris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA.
Shen-Chih ChangDepartment of Epidemiology, UCLA Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA, USA.
Kai-Uwe SaumDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Hendrik DienemannDepartment of Thoracic Surgery, Thoraxklinik at University Hospital Heidelberg, Heidelberg, Germany; Translational Lung Research Center Heidelberg (TLRC-H), Member of the German Center for Lung Research (DZL), Heidelberg, Germany.
Dorothy K HatsukamiDepartment of Psychiatry, University of Minnesota, Minneapolis, MN, USA.
Eric O JohnsonDivision of Health, Social and Economic Research, Research Triangle Institute, International, Research Triangle Park, NC 27709, USA.
Mala PandeDepartment of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Margaret R WrenschDepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.
John McLaughlinPublic Health Ontario, Toronto, Canada.
Vidar SkaugDepartment of Biological and Chemical Work Environment, National Institute of Occupational Health, Oslo, Norway.
Erik H van der HeijdenDepartment for Lung Diseases, Radboud University Medical Centre, Radboud Institute for Health Sciences, Nijmegen, The Netherlands.
Jason WampflerDivision of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN, USA.
Angela WenzlaffDepartment of Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, MI, USA.
Penella WollDepartment of Oncology, University of Sheffield, Sheffield, UK.
Shanbeh ZienolddinyDepartment of Biological and Chemical Work Environment, National Institute of Occupational Health, Oslo, Norway.
Heike BickeböllerDepartment of Genetic Epidemiology, University of Goettingen Medical School, Goettingen, Germany.
Hermann BrennerDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany; Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Eric J DuellUnit of Nutrition, Environment and Cancer, Epidemiology Program, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain.
Aage HaugenDepartment of Biological and Chemical Work Environment, National Institute of Occupational Health, Oslo, Norway.
Irene BrüskeHelmholtz Zentrum München, Institute of Epidemiology I, Munich, Germany.
Lambertus A KiemeneyDepartment for Health Evidence & Department of Urology, Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands.
Philip LazarusDepartment of Pharmaceutical Sciences, Washington State University College of Pharmacy, Spokane, WA, USA.
Loic Le MarchandUniversity of Hawaii Cancer Center, Honolulu, HI, USA.
Geoffrey LiuPrincess Margaret Hospital, Toronto, CA, USA.
Jose MayordomoDivision of Medical Oncology, University of Colorado, Aurora, CO.
Angela RischTranslational Lung Research Center Heidelberg (TLRC-H), Member of the German Center for Lung Research (DZL), Heidelberg, Germany; Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center (DKFZ), Heidelberg, Germany; Div. Molecular Biology, University of Salzburg, Austria; Cancer Cluster Salzburg, Austria.
Ann G SchwartzDepartment of Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, MI, USA.
M Dawn TeareSchool of Health and Related Research, University of Sheffield, Sheffield, UK.
Xifeng WuDepartment of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
John K WienckeDepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.
Ping YangDivision of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN, USA.
Zuo-Feng ZhangDepartment of Epidemiology, UCLA Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA, USA.
Margaret R SpitzBaylor College of Medicine, Houston, TX, USA.
Christopher I AmosDepartment of Community and Family Medicine, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
Laura J BierutDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA; Siteman Cancer Center, Washington University, St. Louis, MO, USA.
Washington University in St. Louis · USHeidelberg University · DEMayo Clinic · USNational Institute of Occupational Health · NONeurological Surgery · USUniversity of California, Los Angeles · USUniversity of Sheffield · GBDartmouth College · USRadboud University Nijmegen · NLThe University of Texas MD Anderson Cancer Center · USUniversity of Göttingen · DEBaylor College of Medicine · USCancer Prevention Institute of California · USCotton (United States) · USGerman Cancer Research Center · DEHelmholtz Zentrum München · DEInstitut d'Investigació Biomédica de Bellvitge · ESLunenfeld-Tanenbaum Research Institute · CAPublic Health Ontario · CARadboud University Medical Center · NL
Funding
Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Fred W Kolling IV · 1985 to 2026
$91.3MTumor Biology and Microenvironment (Program 1)P30CA022453 · NCI · WAYNE STATE UNIVERSITY · PI PAUL M STEMMER · 1985 to 2026
$68.4MUNIVERSITY OF TEXAS--SPORE IN LUNG CANCERP50CA070907 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI HEYMACH, JOHN V. · 1996 to 2024
$57.4MTesting Relapse Recovery Intervention ComponentsP01CA180945 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI COOK, JESSICA MEGAN · 2014 to 2023
$23.0MTHE ROLE OF CAL IN CIF-MEDIATED DEGRADATION OF CFTRP20RR018787 · NCRR · DARTMOUTH COLLEGE · PI STANTON, BRUCE A. · 2003 to 2011
$21.9MGENETIC EPIDEMIOLOGY OF MALIGNANT GLIOMAR01CA052689 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WIENCKE, JOHN K., WRENSCH, MARGARET R. · 1991 to 2015
$20.5MEnhancing the Effectiveness of Varenicline Based Smoking Cessation TreatmentR01HL109031 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI BAKER, TIMOTHY B, STEIN, JAMES H · 2011 to 2020
$17.5MTransdisciplinary Research in Cancer of the Lung (TRICL)U19CA148127 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI AMOS, CHRISTOPHER I., LE MARCHAND, LOIC · 2010 to 2014
$10.9MBIOMARKERS OF LUNG CANCER SUSCEPTIBILITY IN MINORITIESR01ES006717 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WIENCKE, JOHN K. · 1994 to 2009
$8.9MWashington University Institute of Clinical and Translational SciencesKL2TR000450 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$8.8MWashington University Institute of Clinical and Translational Sciences (KL2)KL2RR024994 · NCRR · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2007 to 2011
$8.6MUDP GLUCURONOSYLTRANSFERASES, DETOXIFICATION OF NNKP01CA068384 · NCI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI LAZARUS, PHILIP · 1995 to 2005
$8.5MNCATS NIH HHS KL2 TR000450NCI NIH HHS K07 CA160753NCI NIH HHS N01 PC035145NCI NIH HHS P01 CA068384NCI NIH HHS P01 CA180945NCI NIH HHS P20 CA090578NCI NIH HHS P30 CA022453NCI NIH HHS P30 CA023108NCI NIH HHS P50 CA070907NCI NIH HHS R01 CA052689NCI NIH HHS R01 CA055769NCI NIH HHS R01 CA060691NCI NIH HHS R01 CA074386NCI NIH HHS R01 CA080127NCI NIH HHS R01 CA087895NCI NIH HHS R01 CA090833NCI NIH HHS R01 CA092824NCI NIH HHS R01 CA121197NCI NIH HHS R01 CA127219NCI NIH HHS R03 CA077954NCI NIH HHS T32 CA009142NCI NIH HHS U01 CA096134NCI NIH HHS U19 CA148127NCRR NIH HHS C06 RR020092NCRR NIH HHS KL2 RR024994NCRR NIH HHS P20 RR018787NHLBI NIH HHS R01 HL109031NIDA NIH HHS K08 DA030398NIDA NIH HHS R01 DA011386NIDA NIH HHS R01 DA036583NIDA NIH HHS R01 DA038076NIDA NIH HHS R21 DA033827NIDA NIH HHS R21 DA038241NIDCR NIH HHS R01 DE013158NIEHS NIH HHS R01 ES006717NIEHS NIH HHS R01 ES025460NIEHS NIH HHS R21 ES011667NIGMS NIH HHS R01 GM055874
Abstract
backgroundRecent meta-analyses show that individuals with high risk variants in CHRNA5 on chromosome 15q25 are likely to develop lung cancer earlier than those with low-risk genotypes. The same high-risk genetic variants also predict nicotine dependence and delayed smoking cessation. It is unclear whether smoking cessation confers the same benefits in terms of lung cancer risk reduction for those who possess CHRNA5 risk variants versus those who do not.
methodsMeta-analyses examined the association between smoking cessation and lung cancer risk in 15 studies of individuals with European ancestry who possessed varying rs16969968 genotypes (N=12,690 ever smokers, including 6988 cases of lung cancer and 5702 controls) in the International Lung Cancer Consortium.
resultsSmoking cessation (former vs. current smokers) was associated with a lower likelihood of lung cancer (OR=0.48, 95%CI=0.30-0.75, p=0.0015). Among lung cancer patients, smoking cessation was associated with a 7-year delay in median age of lung cancer diagnosis (HR=0.68, 95%CI=0.61-0.77, p=4.9∗10
conclusionWe demonstrate that quitting smoking is highly beneficial in reducing lung cancer risks for smokers regardless of their CHRNA5 rs16969968 genetic risk status. Smokers with high-risk CHRNA5 genotypes, on average, can largely eliminate their elevated genetic risk for lung cancer by quitting smoking- cutting their risk of lung cancer in half and delaying its onset by 7years for those who develop it. These results: 1) underscore the potential value of smoking cessation for all smokers, 2) suggest that CHRNA5 rs16969968 genotype affects lung cancer diagnosis through its effects on smoking, and 3) have potential value for framing preventive interventions for those who smoke.
Indexed as
Genetic Predisposition to DiseaseGenotypeSmokingSmoking CessationAge of OnsetAllelesCase-Control StudiesHumansLung NeoplasmsNerve Tissue ProteinsOdds RatioPrognosisReceptors, NicotinicRiskCHRNA5 protein, humanNerve Tissue ProteinsReceptors, NicotinicGeneticsLung cancerMeta-analysisSmoking cessation
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